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Apgel (Adapalene)
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Apgel

Apgel works well for treating mild-to-moderate acne, but it can cause burning and itching right after using it. The medication has many different formulations, but only the lower strength gel is available over-the-counter.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Zantac, Caverta, Wellbutrin, Xalatan, Clarinex

Also known as: Adapalene

Description

Differin (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Differin is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.

Dosage

Follow the directions for using this medicine provided by your doctor. Use Apgel exactly as directed. Apgel is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Apgel. Apgel should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Apgel. Continue using Apgel until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Apgel promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.

Storage

Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Apgel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Experimental variables affecting the conformity behavior of children. Antidiuretic effect of 1-propyl-3-p-chlorobenzene-sulfonylurea (chlorpropamide). Susceptibility of mice genetically deficient in the surfactant protein (SP)-A or SP-D gene to pulmonary hypersensitivity induced by antigens and allergens of Aspergillus fumigatus. Interactions between varicella-zoster virus IE62 and cellular transcription factor USF in the coordinate activation of genes 28 and 29. In contrast, the mineralizing and non-mineralizing matrices were clearly distinguished by the silver methenamine method. Congenital dyserythropoietic anemia type II is the most frequent type. Pathologic changes of the eyes were evaluated by histology and immunohistochemistry. A simple triple-lumen drainage tube for gastrointestinal fistulas. This is presumed to lead to sarcolemmal instability which could render muscle fibers susceptible to necrosis. Our method reliably confirmed and mapped the matUPD7 regions in all patients in our study.

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Relatively new are the studies of neuropsychiatric symptoms in neurologic diseases. In this article Nick Castle explains that, with significant improvements being made to the emergency management of cardiac patients, emergency nurses should challenge and develop their clinical practice to ensure patients receive prompt and evidence based treatment. FloSeal use in endoscopic sinus surgery: effect on postoperative bleeding and synechiae formation. The type 2 receptor may be primarily an embryonic receptor involved with cell differentiation and growth and may be induced in disease states. A number of recently published studies have indicated that CR of more than 4 years after rituximab monotherapy may be a regularly occurring event. We analyzed a group of 84 (19 male and 65 female) patients with average age of 45 years. Race and gender differences in the treatment of psychiatric disorders in young adolescents.

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Within seconds of stimulation, LPS and Taxol induce in Lps(n) macrophages a depression of autophosphorylation, followed within minutes by autophosphorylation of both p53 and p56 lyn species. These results suggest that ATP applied to the perfusate provides enough substrate for ecto-protein kinase to induce LTP through phosphorylation of extracellular domains of membrane proteins in CA1 neurons. The results are discussed in relation to the mechanisms of transfer of hexoses and amino acids. This review of recent publications focuses on the role of the organism in peptic ulcer disease, the epidemiology of H. Lowering the blood pressure with diuretic-based therapies has not been shown to delay or prevent the loss of kidney function in patients with this condition, suggesting that this treatment approach may not be optimal. The carboxylases of the Athiorhodaceae are smaller, that of Rhodospirillum rubrum being a 6.2S molecule, and those of the two species of Rhodopseudomonas are 12S and 14.5S. Myeloid lineage involvement in acute lymphoblastic leukemia: a morphology antibody chromosomes (MAC) study. The results suggest that the regulatory eJffect of cortisone on carbohydrate metabolism may be brought about -by its action on the cellular concentration of certain enzyme proteins. Excision of aneurysm of the ascending aorta with prosthetic replacement during cardiopulmonary bypass. The study was designed to compare beneficial and systemic effects of 800 micrograms of inhaled triamcinolone once daily at 3:00 PM (QD group) versus 200 micrograms conventional four times a day dosing (QID group).

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Comparative study of overlapping genes in bacteria, with special reference to Rickettsia prowazekii and Rickettsia conorii. Comparison of energy output during ramp and staircase shortening in frog muscle fibres. Ictal asystole with convulsive syncope mimicking secondary generalisation: a depth electrode study. In addition, synthetic-lethal interactions were observed for double-mutants containing null alleles of SLA2 and SAC6. Some studies on the biosynthesis of aldosterone and other adrenal steroids. With rat-tail type I collagen matrices only lateral but not vertical expansion of endothelial networks was observed.

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IL-13 caused a modest reduction of IL-1 induction of E-selectin and ICAM-1. Thirty-eight infants and young children with gastroenteritis were investigated for lactose malabsorption. IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. An index for fixation suppression of vestibulo-ocular reflex during rotation stimulus was significantly lower in patients with cerebellar dysequilibrium than in normal control subjects and those with peripheral dysequilibrium. Five male adult rhesus monkeys were injected intramuscularly with Abeta(1-15) peptide vaccine at baseline and at weeks 2, 6, 10, 14, 18 and 22. Is artificial hypotension in surgery of the colon and rectum indicated?. In addition, sera from individuals living in a malaria endemic area (and who are presumably immune) contained immunoglobulins specific for this region of band 3. Nutrition is needed not only for the maintenance of physiologic functions but also for growth.

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In six rabbits, silicone oil was perfused into both cerebral ventricles and out through the cisterna magna to physically block exchange of VPA between cerebrospinal fluid (CSF) and blood and between brain and CSF. In normal hepatocytes from control rats, ALPase activity was seen only on the bile canalicular membrane. Twenty-seven participants meeting DSM-IV criteria for SAD with significant public speaking anxiety. The method used (CELICS) allows rapid and direct cloning of genes encoding cell surface receptors. Myelination of central nervous system axons in tissue culture by transplanted oligodendrocytes. Structural equation modeling supported a model in which age-associated increases in processing speed predicted the availability of long-term memory phonological representations for redintegration processes. Our results indicate that spontaneous mutations at the LacZ transgene are tissue specific and dependent on the chromosomal position of the LacZ transgene. Individual difference factors in risky driving: the roles of anger/hostility, conscientiousness, and sensation-seeking. A total of 184 patients with suspected impaired venous drainage of cavernous bodies were examined.

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