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Apgel (Adapalene)

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Apgel works well for treating mild-to-moderate acne, but it can cause burning and itching right after using it. The medication has many different formulations, but only the lower strength gel is available over-the-counter.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Zantac, Caverta, Wellbutrin, Xalatan, Clarinex

Also known as: Adapalene


Differin (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Differin is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Follow the directions for using this medicine provided by your doctor. Use Apgel exactly as directed. Apgel is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Apgel. Apgel should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Apgel. Continue using Apgel until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Apgel promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Apgel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Experimental variables affecting the conformity behavior of children. Antidiuretic effect of 1-propyl-3-p-chlorobenzene-sulfonylurea (chlorpropamide). Susceptibility of mice genetically deficient in the surfactant protein (SP)-A or SP-D gene to pulmonary hypersensitivity induced by antigens and allergens of Aspergillus fumigatus. Interactions between varicella-zoster virus IE62 and cellular transcription factor USF in the coordinate activation of genes 28 and 29. In contrast, the mineralizing and non-mineralizing matrices were clearly distinguished by the silver methenamine method. Congenital dyserythropoietic anemia type II is the most frequent type. Pathologic changes of the eyes were evaluated by histology and immunohistochemistry. A simple triple-lumen drainage tube for gastrointestinal fistulas. This is presumed to lead to sarcolemmal instability which could render muscle fibers susceptible to necrosis. Our method reliably confirmed and mapped the matUPD7 regions in all patients in our study.

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Service paths prior to clinic use by mentally retarded people: a retrospective study. putida TB105 was found to mineralize a benzene, toluene, and p-xylene mixture without accumulation of any metabolic intermediate. We studied the effect of depth weighting in MNE using a shift metric. A caring, compassionate, and comprehensive approach to the care of HIV-infected infants and children results in increased survival and lengthening of disease-free time. In this study, a sensitive measure of physician satisfaction is used to compare physicians working in four types of practice settings: private group practice, solo practice, a closed-panel health maintenance organization (HMO), and a hospital-based practice. The energy transfer function displays the expected up-scale energy transfers. Intravascular infusion of isoproterenol caused active dilatation of pulmonary arteries and veins. In contrast, data pertaining to recurrent herpes simplex indicates that axonal transport of the virus from sensory ganglia to the skin is directed primarily to the epidermis, via terminal non-myelinated nerve twigs. For claudicating patients, medical management includes symptomatic treatment with cilostazol or pentoxifylline.

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Relatively new are the studies of neuropsychiatric symptoms in neurologic diseases. In this article Nick Castle explains that, with significant improvements being made to the emergency management of cardiac patients, emergency nurses should challenge and develop their clinical practice to ensure patients receive prompt and evidence based treatment. FloSeal use in endoscopic sinus surgery: effect on postoperative bleeding and synechiae formation. The type 2 receptor may be primarily an embryonic receptor involved with cell differentiation and growth and may be induced in disease states. A number of recently published studies have indicated that CR of more than 4 years after rituximab monotherapy may be a regularly occurring event. We analyzed a group of 84 (19 male and 65 female) patients with average age of 45 years. Race and gender differences in the treatment of psychiatric disorders in young adolescents.

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Within seconds of stimulation, LPS and Taxol induce in Lps(n) macrophages a depression of autophosphorylation, followed within minutes by autophosphorylation of both p53 and p56 lyn species. These results suggest that ATP applied to the perfusate provides enough substrate for ecto-protein kinase to induce LTP through phosphorylation of extracellular domains of membrane proteins in CA1 neurons. The results are discussed in relation to the mechanisms of transfer of hexoses and amino acids. This review of recent publications focuses on the role of the organism in peptic ulcer disease, the epidemiology of H. Lowering the blood pressure with diuretic-based therapies has not been shown to delay or prevent the loss of kidney function in patients with this condition, suggesting that this treatment approach may not be optimal. The carboxylases of the Athiorhodaceae are smaller, that of Rhodospirillum rubrum being a 6.2S molecule, and those of the two species of Rhodopseudomonas are 12S and 14.5S. Myeloid lineage involvement in acute lymphoblastic leukemia: a morphology antibody chromosomes (MAC) study. The results suggest that the regulatory eJffect of cortisone on carbohydrate metabolism may be brought about -by its action on the cellular concentration of certain enzyme proteins. Excision of aneurysm of the ascending aorta with prosthetic replacement during cardiopulmonary bypass. The study was designed to compare beneficial and systemic effects of 800 micrograms of inhaled triamcinolone once daily at 3:00 PM (QD group) versus 200 micrograms conventional four times a day dosing (QID group).

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Comparative study of overlapping genes in bacteria, with special reference to Rickettsia prowazekii and Rickettsia conorii. Comparison of energy output during ramp and staircase shortening in frog muscle fibres. Ictal asystole with convulsive syncope mimicking secondary generalisation: a depth electrode study. In addition, synthetic-lethal interactions were observed for double-mutants containing null alleles of SLA2 and SAC6. Some studies on the biosynthesis of aldosterone and other adrenal steroids. With rat-tail type I collagen matrices only lateral but not vertical expansion of endothelial networks was observed.

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IL-13 caused a modest reduction of IL-1 induction of E-selectin and ICAM-1. Thirty-eight infants and young children with gastroenteritis were investigated for lactose malabsorption. IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. An index for fixation suppression of vestibulo-ocular reflex during rotation stimulus was significantly lower in patients with cerebellar dysequilibrium than in normal control subjects and those with peripheral dysequilibrium. Five male adult rhesus monkeys were injected intramuscularly with Abeta(1-15) peptide vaccine at baseline and at weeks 2, 6, 10, 14, 18 and 22. Is artificial hypotension in surgery of the colon and rectum indicated?. In addition, sera from individuals living in a malaria endemic area (and who are presumably immune) contained immunoglobulins specific for this region of band 3. Nutrition is needed not only for the maintenance of physiologic functions but also for growth.

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No controlled clinical trials of systemic glucocorticosteroids in sinusitis have been published. EGL-10 protein is localized in neural processes, where it may function in neurotransmitter signaling. At neutral pH and both low and high ionic strengths, the affinities of the nicked forms of beta 2-GPI and Asialo-beta 2-GPI for cardiolipin were both lower than those of their intact forms but similar to that of Domain I.(ABSTRACT TRUNCATED AT 250 WORDS). The targeting of nascent polypeptide chains to the endoplasmic reticulum is mediated by a cytoplasmic ribonucleoprotein, the signal recognition particle (SRP). However, cryptorchidism and varicocele can affect the fertility potential on their own. The presently reported lack of ACT production in PSA-containing BPH nodules may contribute to this by making conditions less optimal for complex formation between PSA and ACT.

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In six rabbits, silicone oil was perfused into both cerebral ventricles and out through the cisterna magna to physically block exchange of VPA between cerebrospinal fluid (CSF) and blood and between brain and CSF. In normal hepatocytes from control rats, ALPase activity was seen only on the bile canalicular membrane. Twenty-seven participants meeting DSM-IV criteria for SAD with significant public speaking anxiety. The method used (CELICS) allows rapid and direct cloning of genes encoding cell surface receptors. Myelination of central nervous system axons in tissue culture by transplanted oligodendrocytes. Structural equation modeling supported a model in which age-associated increases in processing speed predicted the availability of long-term memory phonological representations for redintegration processes. Our results indicate that spontaneous mutations at the LacZ transgene are tissue specific and dependent on the chromosomal position of the LacZ transgene. Individual difference factors in risky driving: the roles of anger/hostility, conscientiousness, and sensation-seeking. A total of 184 patients with suspected impaired venous drainage of cavernous bodies were examined.

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These mice appeared to develop normally and were healthy and fertile. Dust particles and metals in outdoor and indoor air of Upper Silesia. depression, dementia, pain) has rarely been addressed systematically in clinical or epidemiological studies until now. Importance of bacteriologic methods in initiating urine cultures. This review describes the antioxidant chemistry of alpha-tocopherol and evaluates the experimental evidence for the linkage of alpha-tocopherol turnover to cellular metabolism through redox cycles. The results suggest that minoxidil supports the differentiation of human keratinocytes. One of these proteins is complement receptor 1 (CR1, CD35), which in soluble form is capable of inhibiting complement activation in vivo. E-cadherin: aristocort pill a marker for differentiation and invasiveness in prostatic carcinoma. Treatment results of chemoradiotherapy for clinical stage I (T1N0M0) esophageal carcinoma.

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Influence of tibial component posterior slope on in vivo knee kinematics in albenza drug class fixed-bearing total knee arthroplasty. The national, non-institutionalised populations of the United Kingdom, Sweden, Denmark, Germany, The Netherlands, Italy, the United States, and Canada were studied. No evidence of infection or other adverse effects were noted with this technique. The method of gastric emptying of non digestible solids is a valid and reliable study of the gastric emptying and should be carried out in all candidates for endoscopy because it is harmless and easy to perform and evaluate. Risk of tumour seeding after percutaneous radiofrequency ablation for hepatocellular carcinoma. A high-resolution method for slicing and counting radioactivity in polyacrylamide gels. The present experiment was designed to investigate the time course of sustained attention that is known to augment stimulus perception in normal subjects.

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The procedure requires special consideration with respect to incisions, insertion of cannula and ports, establishment and maintenance of pneumoperitoneum with a pressure of 10 mmHg, intraoperative monitoring of maternal end-tidal pCO2, perioperative foetal monitoring and choice of postoperative analgesics. The ability of RECQ1 to promote strand annealing was modulated by ATP binding, which induced a conformational change in the protein. Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. Therefore, there is a need for cell culture models to access the bioactivity of antioxidants. Even in the absence of ganglion cell axons in retinal cryosections due to prior optic nerve transection in ovo, the growth preference for the innermost retina layer was maintained in cryocultures. An enhancement of endothelium-dependent bactrim ds cost without insurance relaxation by natural estrogen (as used in most hormone replacement therapy) may be important in postmenopausal women with established coronary heart disease and may contribute to the acute effect of 17 beta-estradiol on blood flow and its long-term protective effect on the development of coronary artery disease. The effect of insulin on nonesterified fatty acid release from the human leg. Flavour neophobia in gerbils and hamsters was studied by comparing the ingestive/pouching behaviour of these animals when presented with either a familiar unflavoured peanut or a novel one that imparted basic flavours such as sweet, salty, sour, or bitter. Our group tried to determine the feasibility and efficacy of the JoMed distal graft connector using the ZEUS robotic system. These surface parameters require definition to interpret the tissue response to a particular material.

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Prolactin and gonadotropin function in 35 males with alcohol-induced liver disease. Our case report is based on the medical history of a greenhouse worker who had atopic syndrome. Efficient receptors were placed below and above hedge height (1.6 m) between 1 and 20 m downwind from the sprayed area. Clinical findings and morphological and surgical characteristics. The experimental system consists of three model target cell lines, derived from HeLa cells, that stably express one of three interleukin-2 receptor alpha chain (CD25) chimeras, TAC, TAC-CD16, and TAC-DKQTLL, which have identical extracellular domains but different intracellular trafficking itineraries, and a targeted amphotropic murine leukemia retrovirus whose envelope proteins were modified to include a binding site for TAC at their N-termini. A female infant with Pfeiffer syndrome (acrocephalosyndactyly V) is presented. Effects of dexamethasone and growth hormone treatment on hepatic gluconeogenic enzymes in calves.

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A study of surgically excised tumors with special emphasis on localized lesions. We have previously mapped its dsRNA-binding domain (DRBD) to the amino terminal 170 residues (Patel and Sen, 1992). Performance during spontaneous speaking was scored by referencing a transcription of the spoken message to a transcription of the signed message. The aspirate contained many small and large papillary cell groups and numerous single tall columnar cells with apical cytoplasmic projections and mild to moderate degree of nuclear pleomorphism. Since these NO donors were non toxic towards macrophages, these observations indicate clearly that the addition of exogenous NO to that formed by the enzymatic reaction can cause inhibition of the inducible NO synthase. Renal-cell carcinoma is the exception since its frequency of metastases to the head and neck exceeds the expected incidence in the general population. A comparative study of the spontaneous fluctuations with the results of the glycerol test leads us to the conclusion that the observation and measurement of these fluctuations during a follow-up, give us a more reliable evaluation of the fluctuant characteristic of the hearing than does the glycerol test. Gene sequencing identified these infections as Cryptosporidium parvum infections, although they were not identical. Results of long-term follow-up of patients with porphyria cutanea tarda.

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