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Amantadine works against viruses to prevent their growth and multiplication. It also appears to restricts the viruses to release infectious chemicals (viral nucleic acid) to enter into the body. Thus, it prevents and treats Influenza infection.

Other names for this medication:
Amantadine, Amantral, Amantrel, Comantrel, Neaman

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Generic Amantadine is an antiviral medication. It blocks the actions of viruses in your body. Generic name of Generic Amantadine is Amantadine. Amantadine is also known as Amantadine. Brand name of Generic Amantadine is Amantadine.


This section provides information on the proper use of a number of products that contain amantadine. It may not be specific to Symmetrel. Please read with care.

For patients taking amantadine for Parkinson's disease or movement problems (including dyskinesia) caused by certain medicines used to treat nervous, mental, and emotional conditions:

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide or patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. Improvement in the symptoms of Parkinson's disease usually occurs in about 2 days. However, in some patients, this medicine must be taken for up to 2 weeks before the full benefit is seen.

For patients taking amantadine to prevent or treat flu infections:

Talk to your doctor about the possibility of getting a flu shot if you have not had one yet. This medicine is best taken before exposure or right away after exposure to people who have the flu. To help keep yourself from getting the flu, keep taking this medicine for the full time of treatment. Or if you already have the flu, continue taking this medicine for the full time of treatment even if you begin to feel better after a few days. This will help clear up your infection completely. If you stop taking this medicine too soon, your symptoms may return. This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your doctor. If you are using the oral liquid form of amantadine, use a marked measuring spoon, oral syringe, or medicine cup to measure each dose correctly. The average household teaspoon may not hold the right amount of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow whole. Do not crush, break, or chew it. You may also open and sprinkle the extended-release capsules on a teaspoonful of soft food, including applesauce. Take all of the medicine right away without chewing. You may take this medicine with or without food.

Take Osmolex ER™ extended-release tablet in the morning. Swallow whole. Do not crush, open, or chew it.

Do not receive the nasal flu vaccine (live attenuated influenza vaccine) while taking this medicine.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of Parkinson's disease or movement problems (including dyskinesia): For oral dosage forms (extended-release capsules): Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Children—Use and dose must be determined by your doctor. For oral dosage forms (extended-release tablets): Adults—129 milligrams (mg) once a day in the morning. Your doctor may increase your dose each week to a maximum dose of 322 mg (one 129 mg tablet and one 193 mg tablet) once a day taken in the morning. Children—Use and dose must be determined by your doctor. For oral dosage forms (liquid-filled capsules, syrup, and tablets): Adults—100 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Older adults—At first, 100 milligrams (mg) once a day as a single dose. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For the treatment or prevention of flu: For oral dosage forms (capsules, syrup, and tablets): Adults—200 milligrams (mg) or 4 teaspoonfuls once a day as a single dose. Older adults—100 milligrams (mg) once a day as a single dose. Children 9 to 12 years of age—100 milligrams (mg) or 2 teaspoonfuls 2 times a day. Children 1 to 9 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 4.4 to 8.8 milligrams (mg) per kilogram (kg) of body weight per day. The dose is divided evenly and given 2 times a day. However, the dose is usually not more than 150 mg per day. Children younger than 1 year of age—Use and dose must be determined by your doctor.


If you overdose Generic Amantadine and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Symmetrel dosage information

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The most common side effects associated with Amantadine are:

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Appropriate studies have not been performed on the relationship of age to the effects of Gocovri® and Osmolex ER™ in the pediatric population. Safety and efficacy have not been established.

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Gastric peroxidase--localization, catalytic properties and possible role in extrathyroidal thyroid hormone formation. An independent data and safety monitoring board monitored the progress of the study and performed interim analyses of the data. Female athletes are two to eight times more likely to suffer a knee or ankle ligament injury than male athletes, and sex hormones have been considered to play an important role in the injury. (iv) To examine the interaction of ICP0 with cyclin D3, we used a previously described mutant carrying a wild-type ICP0 but expressing cyclin D3 (R7801) and in addition constructed a virus (R7916) that was identical except that it carried the D199A-substituted ICP0. We also observed significant differences in activity between HD and HC and between HD and OCD in regions (ACC, anterior insula, orbitofrontal cortex, and striatum) involved in evaluating stimulus-response-reward associations, or the personal and task-relevant value of stimuli and behavioral responses to stimuli. Southern hybridization was performed on plasmids using restriction fragments of the smallest plasmid as probes. Essentially, a refugee population has the same psychopathology as any other group, and the important thing is that they be understood in the wider frame of reference of their political and cultural background. Effects of triiodo-L-thyronine (T3)-induced hyperthyroidism on the cardiovascular alpha-adrenoceptor system in young and older rats.

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Chickens injected with cycloleucine developed vacuolation of myelin similar to that seen in humans with vitamin B12 deficiency. The neurophysiological responses to upright, inverted and negative faces matured until adulthood and showed different effects at different ages. To evaluate the accuracy of Boey scoring system in predicting postoperative morbidity and mortality in patients operated for peptic perforation. To study the action of pseudoephedrine salicylate on the central nervous system of mice. Overall mean AVA did not differ between methods, suggesting that these three methods are equally accurate in a nonselected clinical patient group. Cross-linking of the photoactivable phospholipids to membrane-embedded proteins, glycophorin A, cytochrome b5, and gramicidin A, was demonstrated. While nevi were negative and only a minority of primary malignant melanoma expressed C4.4A, all metastases were C4.4A-positive. These data support a role for the use of UrNTx and UrDPD in further studies of the patho-physiology of RA and in longitudinal studies designed to modify the course of clinical disease. When administered i.v, at a dose of 14 pmol x kg-1 x min-1, neurotensin increased basal smooth muscle tone and antiperistaltic activity in the proximal colon. Results show that ultrasonic cleaning improves the cleaning efficiency under all experimental conditions.

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Antibodies against neuron specific enolase (NSE) and glial fibrillary acidic protein (GFAP) were used to identify whether neuron and glia contained p300 or SRC-1. injection protocols), suggestive of neuroadaptation to kappa agonists as a class. A retrospective case-series analysis on patients undergoing fluoroscopically guided coil embolization of the GSV and foam sclerotherapy of the GSV and below-knee varices at a single Canadian center. The diagnosis was based on tissue examination in 57 and on the clinical syndrome, including pneumatosis, in 7. Increasing the perfusate calcium concentration caused a dose-dependent increase in heart glycerol 3-phosphorylcholine (GPC) content. Immunohistochemical observation of S-100 protein and neuron specific enolase in the tumour cells of granular cell tumour. We found that only IFN-alpha increased significantly whereas IL-4 decreased both EpCAM and LewisY expression. The signal was automatically analysed, off-line, and 18 parameters were computed from the signal waves. The effect of progesterone (P), estradiol benzoate (EB) plus P, and FSH on the testicular weight, macromolecular content, and incorporation of 3H-leucine, 3H-uridine and 3H-thymidine into macromolecules was examined in the testes of immature chickens. Adolescence is an era of development when individuals start to implement their own features to life.

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Mortality statistics are largely based on death certificates, so it is important that the data on the death certificate is accurate. Resolution of optic disk neovascularization associated with intraocular inflammation. Atrioventricular nodal functional and effective refractory periods and conduction patterns were dependent on both the timing and pattern of engagement at the principal inputs to the atrioventricular node as well as the subsequent organization of activation of the various regions of the atrioventricular node. Two voltammetric methods, based on 1) a dual-plate generator-collector micro-trench electrode (steady state) and 2) a square-wave voltammetry (transient) method, are applied and compared in terms of mechanistic resolution. Both high-sensitivity C-reactive protein (hsCRP) and electron beam computed tomography (EBCT) coronary artery calcification (CAC) are valid markers of cardiovascular risk. Oxidative stress was evaluated by the determination of brain malondialdehyde and reduced glutathione.

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Ratios of tumor SUV relative to the SUV of gray matter, brain (including gray and white matter), or white matter were calculated at each imaging time point. The effectiveness of modularized teaching of illness self-management skills to schizophrenic patients appears to be largely independent of baseline psychology and symptom improvement. However, these large cells had the appearance of empty vesicles and were apparently nonviable as indicated by viable-count experiments. Maternal mortality estimation in France, according to a new method. We report a case of severe biliary complication, associating main bile duct stricture and biliary pleural fistula, arising after extensive RFA for unresectable liver metastasis of central location. Newborn animals developed a disease which was fatal in approximately 1 week whereas most weanlings showed signs of an acute disease after day 8, from which a significant number recovered. The need to assemble a large enough series to make statistically significant conclusions regarding this infrequent condition is highlighted throughout the literature, which is reviewed here. However, upon the shift there was an increase in the frequency of cells having new sites, which was due to the faster-growing cells initiating more new sites in peripheral locations before division. The first paper discussed the application of clinical decision analysis to diagnostic tests, particularly audiological tests. We describe a case with scleroderma and angiomatous vascular proliferation as skin alterations which may be involved in this syndrome.

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Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics. Re-treatment of multiple drug-resistant tuberculosis remains a difficult therapeutic problem. The goal of our study was to investigate the influence of aprotinin on the synthesis of von Willebrand factor (vWF protonix ) in human endothelial cells. Comparison of histone variant synthesis in human lymphocytic leukemia cells and in normal lymphocytes. The model simulates the mechanical properties of lung parenchyma, alveolar gas, bronchial wall, and cheeks, as well as the distribution of gaseous resistances and inertances within the airways. Although factors independently associated with readmission were not surprising (e.g. Additionally, mannose glycoconjugates were not effective inhibitors of phagocytosis. Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications. The regression of atretic oocytes in Perca fluviatilis was studied by histochemical, light and electron microscopic methods. Etiological and physiopathological significance of atrial natriuretic peptide activity in essential hypertension.

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Review of peripartum hysterectomy rates at a tertiary Australian hospital. The EMSOP group recommends use of pulse oximetry, peak expiratory flow rate, and the visual analog dyspnea scale as potential risk-adjustment measures and outcome measures for out-of-hospital research in patients with respiratory distress. Partial trisomy 20p syndrome in an uncle and niece are compared to 32 previous cases. In this study, a pH-sensitive copolymer was synthesized and employed to investigate the flocculation behaviors of kaolin by focused beam reflectance measurement (FBRM). T-cell ratio, lymphocyte blastoformation following PHA stimulation, PPD and DNCB skin tests, and phagocytosis test of peripheral leucocytes were studied. Both cochlear implantation and deaf education are widely cost effective in Latin America. For example, both local and systemic recurrences (worsening after initial improvement) with intact or fragmented immunoglobulin antivenoms have been observed. Rabbits sensitized systemically to ovalbumin displayed skin reactions of the Arthur type and high titers of circulating antibodies. This article gives a short overview of the state-of-the-art techniques for computational promoter localization and analysis, and comments on the most recent advances in the field.

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Here, we study the interplay of curvature elasticity, membrane-substrate adhesion, and constriction forces to obtain generalized stability conditions for closed necks which we validate by numerical energy minimization. Because this diagnosis may be difficult to make when intercoronary anastomoses are inadequate to outline the left anterior descending coronary flow into the PA, patients with clinical findings suggestive of anomalous coronary artery may require selective coronary studies to exclude this anomaly. Routine ultrasonography can detect many abnormalities in low-risk fetuses, but may pose dilemmas for midwives counselling parents, a new study shows. In contrast, BDNF elicited small but significant calbindin responses. This strategy indicated that in transformed human NBE cells, the NS-1 protein is indispensable for MVMp DNA replication, trans activation of the late parvoviral promoter P38, trans inhibition of the long terminal repeat promoter of the Rous sarcoma virus, and cytotoxicity.

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These data suggest that certain populations of antibody in group C streptococcal antisera may participate in tissue reactivity via interaction with cell surface glycoproteins, including immunoglobulin G. The particle-particle potential of mean force exhibits multiple qualitatively different behaviors (contact aggregation, steric stabilization, local bridging attraction) depending on the strength and spatial range of the polymer-particle attraction. Effect of atrial natriuretic factor (ANF) on water homeostasis of the neonate. In this system, PTX was found to inhibit the secretion of both TNF-alpha and IL-6 by T cells. The lipases uncover an immunological determinant that is found on other glycosylphosphatidylinositol-anchored membrane proteins after the same treatment. However, immunohistochemistry has not routinely been subjected to similar standardization and quality assurance procedures that manufacturers and pathologists alike have applied to essentially the same techniques in the clinical laboratory environment. The position and extent of the Ace locus, as well as the types of transcripts found, is consistent with the recent findings which identified Torpedo-AChE homologous cDNA sequences in this region. However, below 24 degrees C the apparent activation energy for this activity was less in MH than normal ghosts.

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The level of expression of each of the virus-induced species was dependent upon the multiplicity of infection, and all virus-induced activities exhibited biochemical properties characteristic of purified HSV-1 alkaline nuclease, including activation and inhibition by specifications. If the volume of fluid collected is low, culture and polarizing microscopy have highest priority. It has been instrumental to our understanding of biology in many ways, such as in the discovery of the Gram strain and the identification of nucleic acid as the hereditary material. Similarly, the guinea pig trachea and the rabbit mesenteric vein contain NK-A and NK-P functional sites. A symposium in honor of Professor Bo Forslind on the occasion of his retirement.

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