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Altrol (Anastrozole)
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Altrol

Altrol is a selective non-steroidal aromatase inhibitor. Aromatase is a protein in your body that produces estrogen, which can promote the growth of some cancer cells. By blocking aromatase, Altrol lowers the body's normal production of estrogen. Without estrogen, some breast cancer cells can't grow.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Cardura, Ceclor, Imovane, Anafranil, Suprax

Also known as: Anastrozole

Description

Altrol is approved to treat certain types of breast cancer in women who’ve gone through menopause.

What breast cancer is

Breast cancer develops when cells in your breast start to grow and multiply (make more cells) more quickly than usual. With most breast cancers, the abnormal cells are encouraged to grow by the hormone estrogen.

If your breast cancer is stimulated by hormones, such as estrogen, certain tests will show that the cancer cells have receptors (attachment sites) for those hormones. This type of breast cancer is called hormone receptor-positive (HR+).

HR+ cancers can be treated with hormone therapies that lower the estrogen level in your body. And because most breast cancer is HR+, hormone therapies are also sometimes used to treat breast cancer whose receptor status isn’t known.

What Altrol does

Altrol is a hormone therapy that’s used to treat certain forms of breast cancer. It’s a type of drug called an aromatase inhibitor. Altrol works by stopping (inhibiting) the action of an enzyme called aromatase. (Enzymes are certain proteins that help chemical reactions to happen inside your body.)

The aromatase enzyme makes estrogen out of steroid hormones in your body, such as testosterone. Aromatase is found in various tissues, including your brain, fat, and skin.

Before menopause, estrogen is mainly produced by your ovaries. And just a small amount is made by the aromatase enzyme. But after menopause, your ovaries stop producing estrogen. At that point, the aromatase enzyme is the main way that your body makes estrogen. (And in men, estrogen is also mainly produced by the aromatase enzyme.)

By stopping aromatase from working, Altrol lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

How long does it take to work?

Altrol will start working soon after you begin taking it. But you won’t be able to notice this. Your doctor may order different kinds of tests during your treatment to check and see if the drug is working for you.

Dosage

Usual Adult Dose for Breast Cancer:

Initial dose: 1 mg orally taken once a day Duration of therapy: Until tumor progression (treatment of advanced breast cancer); unknown (adjuvant treatment of early breast cancer) Uses: -Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer; -First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer; -Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

Detailed Arimidex dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Altrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Arimidex if you are allergic to anastrozole, or if you have not yet completed menopause.

Arimidex is not approved for use in men or children.

You should not take anastrozole if you also take tamoxifen.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

heart problems; coronary artery disease (clogged artery disease); high cholesterol; or osteoporosis or low bone mineral density.

Hormonal cancer treatment can weaken your bones. You may be more likely to have a broken bone while using Arimidex. Talk with your doctor about ways to keep your bones healthy.

Although it is not likely that a postmenopausal woman would be pregnant, anastrozole may harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control if you are not past menopause. Keep using birth control for at least 3 weeks after your last dose of Arimidex. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

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To describe a 30-year experience with surgically treated culture-positive active endocarditis. Cytochemical studies of nucleic acids and proteins in erythrocytic development. It is concluded that deamination of adenine nucleotides does not play any role in accumulation of preformed ammonia in senile animals. A specific human sequence in 6q21-22 was amplified by PCR in senescent cells, suggesting that this region harbors a gene inducing senescence. Special fields with demand management require the availability of a vacant SHI physician position. A long range restriction map of the contig has been constructed to establish the order of and distance between loci. Anti-hirudin monoclonal antibodies directed toward discontinuous epitopes of the hirudin amino-terminal and epitopes involving the carboxy-terminal hirudin amino acids. We conclude that the PET has an acceptable agreement with MTCX even during acute peritonitis, so the PET can be a useful tool in evaluating peritonitis-induced peritoneal permeability changes. CSF cytological examination revealed an increased level of atypical histiocytes.

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Experiments manipulating the microenvironment of an IgM secreting cell line revealed that the addition of low concentrations of the reducing reagent 2-mercaptoethanol to the culture medium would enhance the proportions of monomeric IgM in the culture supernatant and the cellular cytoplasmic lysate. Patients were randomly assigned to undergo serial testing of the efficacy of the seven antiarrhythmic drugs by one of two strategies: electrophysiologic study or Holter monitoring together with exercise testing. Transfection experiments performed with the human skin keratinocyte cell line RTS3b and P7535 reporter plasmids revealed transactivation at low amounts and a repression of basal promoter activity at high amounts of E2 expression vector. Educational role of a nurse towards patients addicted to smoking--on spa treatment. Risk factors and pathologic findings seem to support an ischaemic pathogenesis in both diseases. Careful angiographic evaluation of the vertebrobasilar circulation is important for management of patients with os odontoideum. However, the lack of variation of these values from two compounds indicates a lack of dependence on the octanol/water coefficient which is in accord with the model. Processing of defined T-cell epitopes after phagocytosis of intact bacteria by macrophages. This paper proposes a simple approach to can a breastfeeding mother take xanax the parametric derivation of age-related reference ranges which avoids the creation of arbitrary age groups, copes easily with a non-linear relation between variability and age, and is computationally simple. Our data demonstrate that allergens as NiCl2 and CoCl2 are capable of directly activating endothelium which is an important step in evolving inflammatory reactions and may thus be of relevance for the pathogenesis of contact hypersensitivity.

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The 28-kDa protein was found to be a thermostable uroporphyrinogen III methylase. Peptide binding sites recognized by anti-mucin (MUC2) monoclonal antibodies. A group of fluorene-based polymers, PF-1SOR and PF-2SOR, were synthesized and characterized as blue light-emitting materials. By gaining a greater understanding of these cultural traditions and practices, we can deliver more culturally sensitive health care to the Chinese patient and family. In vivo expression of the antimicrobial defensin and lactoferrin proteins allowed by the strategic insertion of introns adequately spliced. RON specific transcripts were detectable in mouse liver from early embryonal life (day 12.5 p.c.) through adult life. Autotransfusion with leap-frog technique in patients with coronary heart disease and planned aortocoronary venous bypass.

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Distribution of calretinin, calbindin D28k, and parvalbumin in subcellular fractions of rat cerebellum: effects of calcium. These efforts will be stronger if they are concurrent and mutually reinforcing, and are viewed as the constituent parts to a greater vision for the well-being of our youth. Self-reported health problems and physical symptomatology in adolescent alcohol abusers. In suspension culture, the amounts of induced piceatannol and resveratrol were somewhat lower. Survival rates of 2 homozygous strains of mice and the F-1 generation of their hybrids. Lipofucsin granules and multivesicular bodies also were distinguished in endothelial and pericyte cells. My experiences in opthalmological activity at the Bad Elster federal baths. State laboratories provide testing for surveillance programmes and export purposes, in addition to diagnosis of clinical cases. Three fluorescence peaks were identified in EEM fluorescence spectra of the EPS samples. Primary hepatic carcinoid tumor: one Egyptian center experience.

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Patients with severe TBI and patients with IH have similar increments in metabolic rate during the initial phase (1 week from onset) of their disease. The determinants of immune recognition by five monoclonal antibodies (KK5, KK9, KK17, Senv7.1, and Senv101.1) that neutralize simian immunodeficiency virus infectivity were analyzed. Transport of IgG across the blood-luminal barrier of the male reproductive tract of the rat and the effect of estradiol administration on reabsorption of fluid and IgG by the epididymal ducts. In the present study, we extended these findings by testing whether these high and low metastatic colonic carcinoma cells differ in their adhesion efficiency to is xanax a scheduled drug E-selectin-expressing cells. Ultrastructural effects of diclazuril against Toxoplasma gondii and investigation of a diclazuril-resistant mutant.

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Immunological reactions to skin homotransplantation in rabbits and rats. Interview with Professor Giovanni Bonfiglio, founder and director of the Istituto Italiano di Alcoolismo. Studies on the histogenesis of the tunica mucosa of the stomach of the Egyptian water buffalo (Bos bubalus L.). Reflection of internal and external tenormin 50 mg cost determinants of behavior in the neuronal activity of the neostriatum of monkeys. MantADP was highly protected from the quencher when bound to the active site of S1. A study of serum glycoproteids (hexose) in pulmonary tuberculosis. Neutrophil-derived adhesion molecules in human digital ischaemia and reperfusion. Extended studies in human experimental endotoxemia showed that pentoxifylline decreased circulating TNF without affecting endogenous formation of interleukins.

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