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Alpostin (Alprostadil)

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Alpostin is a prescription medicine used to treat the symptoms of Erectile Dysfunction (impotence). Alpostin may be used alone or with other medications. Alpostin belongs to a class of drugs called Prostaglandins, Genitourinary.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Also known as: Alprostadil


Alpostin urethral suppository is used to treat men who have erectile dysfunction (also called sexual impotence). It belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. This medicine causes an erection because it increases the blood flow to the penis.

Alpostin should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Suppository


Alpostin is produced in a liquid form and is administered by injecting it directly into the side of the penis. It is important to make sure that you understand how to do this properly. If you are unsure, consult your doctor or healthcare provider. For the purposes of injecting this medication, always choose a less visible blood vessel. After injecting the medication, apply pressure to the affected area with an alcohol swab for about 5 minutes to avoid bruising. The injection must not be administrated close to the surface of the skin, at the top or head of the penis or at the base of the penis near the scrotum or testes. According to the etiology of the erectile dysfunction, the initial dose may vary: - For vasculogenic or psychogenic erectile dysfunction, or for erectile dysfunction of mixed etiology, the starting dose is 2.5mcg. If there is no effect, you may increase the dose to 5mcg, followed by increments of 5–10mcg until the desired result (dose produces an erection for appropriate sexual intercourse and it doesn't last more than 1 hour). If there is still no response to the initial dose, you may give a second dose of 7.5mcg within one hour, followed by increments of 5–10mcg until the desired result is achieved. - For erectile disorders of neurogenic etiology, the recommended dose is 1.25mcg. You may increase the second dose to 2.5mcg, and the third dose to 5mcg, followed by increments of 5mcg until the desired result is achieved. The maximum dose is 60mcg per day. Allow a 24 hour interval between doses. Use Alpostin only as needed. Do not take a double dose of Alpostin.


If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately. The overdose of the medication may be followed by feeling light-headed, fainting, having a painful or prolonged erection lasting 4 hours or longer.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store unopened foil pouches in the refrigerator. Keep the medicine away from heat. It may not work if exposed to temperatures above 30 degrees C. You may also store the suppositories at room temperature for up to 14 days before each use.

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use alprostadil if you are allergic to it, or if you have:

sickle cell anemia or the sickle cell trait; leukemia; a tumor of the bone marrow (multiple myeloma); a curved or deformed penis; penile fibrosis or Peyronie's disease; if you have a penile implant; or if you must avoid sexual intercourse for health reasons.

Tell your doctor if you have ever had:

heart disease; high or low blood pressure; or bleeding problems.

Caverject, Caverject Impulse, Edex, or Muse should not be used by women or by anyone under 18 years old.

While using alprostadil pellets, use condoms during sex if your partner is pregnant or able to get pregnant. The effects of alprostadil on an unborn baby at conception or during pregnancy are unknown.

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