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Thymidine kinases and deoxyribonucleic acid synthesis in normal and regenerating rat liver. As regulation of transgene expression would be preferable for conducting clinical trials for reasons of safety, we investigated whether intraperitoneal (i.p.) administration of retroviral vector-transduced fibroblasts encoding murine interferon-alpha (IFN-alpha) could have therapeutic activity, and compared its effect with the antitumor effects of fibroblasts producing IFN-alpha under a rapamycin analogue (AP21967)-inducible promoter. Health education on eye care and early warning signs should be encouraged. Mice with hereditary obesity and hyperglycemia as objects for diabetes research. Hepatitis C virus genotypes are not responsible for development of serious liver disease. Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. PHE concentrations of 0.3 to 0.6 mmol/kg brain tissue were obtained, resulting in a concentration gradient for PHE between blood and brain tissue of 2.4 to 3.0. Reproducibility of results obtained by the Treponema pallidum immobilization test in South Africa.
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Low-molecular-weight-dextran (Dextran-40) is a useful adjunctive anti-platelet agent in the setting of coronary angioplasty and intracoronary stent placement. First diagnostic effort revealed a cystic mass on the pelvic floor, compressing the colon and other neighbouring organs. There was a statistically significant difference in average drop size and cost among the three studied drugs. By this method we were able to consistently amplify bcr-abl transcripts from as few as 10 cells. In particular, that data are reliable in order to produce meaningful results. A reference dose is obtained by dividing a no-observed-effect level by uncertainty (safety) factors to account for intraspecies and interspecies sensitivities to a chemical. As expected, faster stimulus rates resulted in longer ABR component wave latencies. The alteration yields an enzyme that serves as an effective catalyst for both longer straight-chain primary alcohols and branched chain alcohols.
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There was no significant difference between the two groups on any measure, and in the depressed patients there was no significant relation between CSF concentrations of TRH and thyrotropin-stimulating hormone responses to TRH infusion. Overall, the results reported here were consistent with the conclusion that CTP synthetase was regulated by protein kinase C phosphorylation. As these effects could be stimulated by reduction in the forelimb blood supply it is probable that the changes in cutaneous corpuscle responsiveness following sympathetic stimulation are caused by local changes in blood flow. Evaluation and results of the treatment of post-traumatic lesions of long bone shafts. A comparison was made of the histological findings for myocardial tissue of heterotopic transplanted rat hearts administered with FK506. To assess similarities and differences in antibody responses to recombinant (r) HIV-1IIIB gp120 in chimpanzees, previously protected from HIV-1 infection, and human volunteers immunized in connection with a Phase I clinical trial. Two of the patients were treated with low-dose intravenous enzyme replacement (Ceredase).
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DNA replication-initiation protein Cdc6 was cleaved after 12 h treatment with NCTD. Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. The diagnosis is based on the combination of direct identification and search for a rise in antibody titer by serologic testing. Our findings suggest that Bergmann glial cells contain the molecular machinary to synthesize the NMDA receptor 2B subunit. In all cases, chromosomes described as monosomic were shown to be involved in unbalanced translocations with concurrent loss and/or gain of chromosomal material. The fourth patient elected to continue etanercept treatment and experienced no further deterioration in visual acuity. Following removal of the Fc part, both mAbs internalized at the same rate as IgG2a, indicating that the Fc part of IgG1 is involved in enhanced cellular uptake. A small but significant part of the total information in the message accumulates gradually over the entire course of the response.
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In this time faecal weight and faecal fat excretion were reduced when compared with the results of similar collections (baseline study, and following the ingestion of pancreatic supplements) performed before the administration of ondansetron. Type 2 (nfxB-type) mutants showed cross-resistance to quinolones and new cephems, i.e., cefpirome and cefozopran, concomitant with overproduction of an outer membrane protein with an apparent molecular mass of 54 kDa (OprJ). What ethical dilemmas are encountered by a researcher in conducting research?. All observations can be interpreted on the basis of charge inversion taking place via a long-lived chemical complex. Whether TFIID tau participates in rpL32 gene transcription by binding directly to a promoter element or through another protein has not been resolved. Interaction of the 106-126 prion peptide with lipid membranes and potential implication for neurotoxicity. Subjects were more confident when correct than when incorrect, and the difference was greater when the task was easier. The value of prediction formulas and the prediction of a criterium. Like multiple current dipole modeling methods, FOCUSS produces high resolution solutions appropriate for the highly localized sources often encountered in electromagnetic imaging. The mean surviving area of the dorsal flaps was best for nonsmoking rats, worse for only preoperatively smoking rats, and worst for preoperatively and postoperatively smoking rats.
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In conclusion, we were able for the first time to delineate an intersecting genetic pattern linking ovarian tissues reflective of low potential malignancy/early cancer onset stages via long distance signaling between tissues of gynecological origin. This may be due to a flow-mediated decrease in coronary vasomotor tone and/or the occurrence of vascular remodeling with an enlargement of the coronary arteries. Familial clustering for features of the metabolic syndrome: the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Subunit a of cytochrome o oxidase requires both YidC and SecYEG for membrane insertion. The stomach of the rock hyrax (Procavia habessinica) is divided into a non glandular part with very slow movements, and a glandular part which rapidly mix the digesta. Nearly all of Fast Blue positive neuronal perikarya were apposed by nerve fibers and terminals exhibiting immunoreactivity to secretoneurin. Assembly of very low density lipoproteins in rat liver: a study of nascent particles recovered from the rough endoplasmic reticulum. The prevalence of thyroid antibodies in 100 patients with rheumatoid arthritis in Northern Norway was studied. All but one of seven MAbs specific for antigenic sites I, IV and bridge site (I and II) reacted with the antigen that had been denatured by sodium dodecyl sulfate or 2-mercaptoethanol, as well as with the denatured N protein in Western blotting assays. This is the first report on the clastogenicity of these elements in mouse in vivo.
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Murray Valley encephalitis, Ross River and antigenically related viruses are widespread in Papua New Guinea and Irian Jaya, particularly in the lowland and coastal areas. We now provide new information about these children and describe a fourth case. Hormonal profiles during the second treated cycle show that preovulatory gonadotropin surge is blunted and that no significant progesterone secretion occurs. Strong leadership is required to overcome the bureaucratic and financial obstacles. Analysis of human extrachromosomal DNA elements originating from different beta-satellite subfamilies. 2,2,6,6-Tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC) is a topographically and conformationally restricted, nitroxide containing, C(alpha)-tetrasubstituted alpha-amino acid. Cyclonic ash appeared more efficient than lime in both reducing oxidative stress in beans and Zn, Cu and Pb uptake in grasses. It suggested quartz could cause cell permeability significantly increased, cleavage of peptide-chain of membrane protein, degradation and cross-linkage of protein, and cell damage, but organic selenium could decrease cytotoxicity caused by quartz dust and protect cells from the damage. The identification was consistent with the results of biochemical tests used to characterize the two genera. Retrograde injection of sodium taurocholate in the main pancreatic duct of the isolated perfused pancreas resulted in a steep increase of amylase and lipase in the portal effluate.
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Elevated plasma insulin levels may contribute to the development of hypertension through renal sodium reabsorption, the sympathetic nervous system, the transmembranous cation transport, the renin-angiotensin system, the cardiovascular reactivity, and the atrial natriuretic peptide. The kinetics of dehydration of carbonic acid at 25 degrees and 37 degreesl. The obvious costs of antibiotic treatment include drugs, equipment with which to give them, and assays. However, IL-4 did not modify the secretion of interleukin-6 or tumor necrosis factor. There is no evidence that morbidity and cost differ between the pedicled flap and free tissue transfer reconstruction strategies, other than lengthier operating room time for FRF. Sotalol, an adrenergic-blocking and antiarrhythmic agent, increases markedly and simultaneously the duration of both action potentials and contractions in papillary muscles. Only the half-life of 60Co exceeds 3 months, thus a moderately long storage of the generator reduces the activity, and its disposal is then safe. Sequence analysis indicated that the cDNA had an open reading frame encoding 467 amino acid residues containing a DNA binding motif, known as the high mobility group (HMG) box. A prospective study of 20 patients with a mean follow-up of 26 months. We focused on the oxidative status of the brain by examining selected oxidative markers in brains of SMP30 KO mice.
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During the study period 32 cases of prostate cancer were diagnosed: 12 were detected during the 12 months of the controlled study and were evenly distributed among the treatment groups (4 on placebo, and 3 on 1 mg and 5 on 5 mg finasteride) and 20 cases were detected in the extension study. Influence of different factors on the adsorption of carbofuran (2, 3-dihydro-2,2-dimethyl-7-benzofuranyl-N-methyl carbamate) on soils. GAME: a computer graphics method for calculating and displaying the molecular electrostatic potential. Perineometer measurements of maximum pressure, average pressure, and total duration were recorded for 3 consecutive pelvic floor muscle contractions (Kegels). A controlled drug delivery system with prolonged residence time in the stomach is of particular interest for drugs that i) are locally active in the stomach, ii) have an absorption window in the stomach or in the upper small intestine, iii) are unstable in the intestinal or colonic environment, or iv) exhibit low solubility at high pH values. The severity of the injury increases by increasing the rate of deceleration and decreasing the distance through which the body is decelerated.
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A close relationship between postischemic contractile recovery of the perfused heart and depression in the Vmax value of the ventricular muscle was also observed. A new diterpenoid, megathyrin A, together with three known compounds, rabdocoetsins B, C, and D, were isolated from the leaves of Isodon megathyrsus, and their structures and nmr spectral data were assigned by a combination of one- and two-dimensional nmr techniques. Thus, IVUS measurements may become the gold standard for the acute, chronic, and serial assessment of stent implantation procedures. Isoelectric focusing subtypes of HLA-A can be defined by oligonucleotide typing. SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects. The analysis of dystrophin gene expression has led to the identification of multiple transcripts and varying isoforms. Symptom severity as a predictor of reported differences of prehospital delay between medical records and structured interviews among patients with AMI. Detection of insulin-like growth factor binding protein-1 in cat implantation sites.
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Prognosis may also be predicted from specific gene alterations in cancers. Using the ultrasonic DGH 5100 device, CCT measurements were performed at 9 am, 6 pm, 10:30 pm and the next day at 6 am in bed before the patient gets up. Residents and gynecologists received a survey regarding performance of hysteroscopy, self-perceived competency, and factors influencing hysteroscopic training. When optimal tumor cell kill is achieved, the next step is to address the circadian aspects of normal organs, including the proliferative behavior of tissues with rapid cell renewal. Following the introduction of neonatal intensive care, spastic CP rates have fallen amongst heavier (greater than or equal to 2500 g) infants and remained steady or risen amongst low birthweight (LBW: less than 2500 g) infants. Although the combination initially killed 6-7 logs of a dual-resistant strain lacking OprD and overexpressing MexXY, it could not prevent the emergence of resistance when the 250 mg dose of imipenem was simulated in the combination. For tumors like paraganglioma extending into the petrous bone, the juxtacondylar approach can be combined with an infratemporal approach. Alteration of the pharmacokinetics of sodium cyanide by sodium thiosulfate. Immunolocalization of CD44 and heparan sulfate chains on the stratum intermedium and papillary layer in the rat enamel organ.