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Alfatrim (Trimethoprim)

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Alfatrim (generic name: Co-trimoxazole; brand names include: Septra / Ciplin / Septrin) is a combination of two antibiotics (trimethoprim and sulfamethoxazole) used to treat a wide variety of bacterial infections.

Other names for this medication:
Actrim, Altavit, Anitrim, Assepium, Astrim, Bacsul, Bactelan, Balkatrin, Bascul, Bioprim, Bitrim, Cadiprim, Canibioprim, Chemitrim, Comox, Dientrin, Doctrim, Drylin, Epitrim, Eusaprim, Gentrim, Ifitrim, Infatrim, Kaftrim, Kepinol, Lapikot, Metoxiprim, Neoset, Nopil, Oribact, Politrim, Primazole, Septrin, Sulfamethoxazol, Sulfatalpin, Sulfatrim, Sulfoid, Sulphytrim, Sulprim, Sumetrolim, Supreme, Trifen, Trimethox, Trimezol, Trisolvat, Tritenk, Trizole

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Also known as: Trimethoprim


This medication is used to treat a wide variety of bacterial infections. It is also used to treat a certain type of pneumonia (pneumocystis pneumonia) in patients with a weakened immune system. This medication is a combination of 2 antibiotics: sulfamethoxazole and trimethoprim. It works by stopping the growth of bacteria and the pneumocystis fungus.


Take this medication by mouth, as directed by your doctor, with a full glass of water (8 ounces / 240 milliliters). If stomach upset occurs, take with food or milk. Drink plenty of fluids while taking this medication to lower the unlikely risk of kidney stones forming, unless your doctor advises you otherwise. Dosage is based on your medical condition and response to treatment. Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping it too early may allow bacteria to continue to grow, which may result in a relapse of the infection. Tell your doctor if your condition persists or worsens.


If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes.


Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Alfatrim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before using sulfamethoxazole with trimethoprim, tell your doctor or pharmacist if you are allergic to sulfa medications or trimethoprim; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, certain blood disorders (such as porphyria, anemia due to folate vitamin deficiency), history of blood disorders caused by trimethoprim or sulfa medications, vitamin deficiency (folate or folic acid), severe allergies, asthma, decreased bone marrow function (bone marrow suppression), a certain metabolic disorder (G6PD deficiency), underactive thyroid, mineral imbalances (such as high level of potassium or low level of sodium in the blood). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors. If you have diabetes, this product may affect your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of low blood sugar (see Side Effects section). Your doctor may need to adjust your diabetes medication, exercise program, or diet. Older adults may be more sensitive to the side effects of this drug, especially skin reactions, blood disorders, easy bleeding/bruising, and a high potassium blood level. Patients with AIDS may be more sensitive to the side effects of this drug, especially skin reactions, fever, and blood disorders. This medication is not recommended for use during pregnancy especially near the expected delivery date because of possible harm to the unborn baby. Consult your doctor for more details. This drug passes into breast milk. While there have been no reports of harm to healthy infants, this drug may have undesirable effects on infants who are ill or premature or have certain disorders (jaundice, high blood levels of bilirubin, G6PD deficiency). Therefore, breast-feeding is not recommended for infants with these conditions. Consult your doctor before breast-feeding.

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Direct binding of yeast transcription factor (TFIID) to the ribosomal protein L32 (rpL32) TATA-less promoter sequence. Comparison of earphone and sound field methods for estimating noise attenuation of foam earplugs. Additionally, NeuroD1 induced expression of Nkx2.2, a transcription factor expressed in beta- but not delta-cells. To investigate whether T cell migration into different sites of inflammation (skin and synovium) within the same individual is principally regulated by tissue-specific homing or by more general mechanisms related to inflammation. Protection of the bovine fetus from bovine viral diarrhoea virus by means of a new inactivated vaccine.

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A similar morphological change was observed with another protein-tyrosine kinase inhibitor, herbimycin A. Identification of the in vivo phosphorylated sites of secreted osteopontin from cultured chicken osteoblasts. Current ways of preventing postresectional bronchial fistulas in pulmonary tuberculosis. The Dotter retriever and pigtail catheter: efficacy in extraction of chronic transvenous pacemaker leads. The role of radiotherapy has been demonstrated in a few subgroups of patients. Lumbar puncture showed cerebrospinal fluid containing protein 156 mg/dl, glucose 94 mg/dl, and 5888 polymorphonuclear cells. However, previous studies on tumor growth have not yet revealed how the transition to an angiogenetic state in ovarian malignancy is reflected in the vascular architecture of the ovary.

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On the apraxia-gnostic syndrome and its various forms in focal vascular diseases of the right and left hemisphere of the brain. Finally, CT scans allowed the diagnosis of hemorrhage versus ischaemia and repeat scans demonstrated the evolution of the lesion. Such observations have long puzzled researchers across disciplines and raised serious questions regarding the role of the auditory cortex in encoding ongoing acoustic signals. In contrast, the apparent molecular weights of the alpha- and beta-subunits originating from tissue were both 55 kDa. This article describes six cases of gingival cysts that exhibit the histologic features of the odontogenic keratocyst. Investigation of factors influencing folate status in women who have had a neural tube defect-affected infant.

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However, the intermediate filament desmin could only be found on a small number of tumor cells. MK-801 at 0.1 mg/kg dose further decreased the body temperature during abrupt withdrawal in morphine-dependent mice. The experimental results have further proved the correctness of our theoretical analysis and confirmed that our method is able to suppress double-frequency fringes in the retrieved amplitude map and the distortions in the phase map that are introduced by phase-shift errors such as to effectively eliminate the wave ripples and wall-like structures that are present in the unwrapped phase map owing to these errors. In mammals, the transmembrane protein kinase/endoribonuclease IRE1 is activated by endoplasmic reticulum stress and subsequently processes XBP1 mRNA to generate an active form of XBP1 protein. We review the basis for newer approaches to the treatment of heart failure and discuss some of the agents which capitalize on current understanding of the underlying patho-physiology. Fibrinogen Detroit--a molecular defect in the N-terminal disulphide knot of human fibrinogen?.

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These results indicated that IL-13 and IL-4 inhibit bone resorption by suppressing COX-2-dependent PG synthesis in osteoblasts. The development of chromosome-specific composite DNA probes for the mouse and their application to chromosome painting. The modulation of NO did not alter HGF-induced chemoinvasion of endothelial cells, while spermine-NONOate destabilized HGF-induced tubulogenesis, suggesting that a single assay is not sufficient for predicting the final phenotypic outcome on angiogenesis. Two of these children had septicemia from Candida organisms secondary to these venous lines. Patients who underwent cesarean delivery were assigned randomly to either 200-microg misoprostol or placebo placed in the buccal space. Studies of the past decade featuring relevant neuropsychiatric disorders as well as disorders in child psychiatry are reviewed. Here, we compared the killing pathways mediated by each receptor molecule in TNF-sensitive L929 cells stably transfected with APO-1/Fas cDNA. Study of referral process between general practitioners and specialists in health insurance clinics in Alexandria.

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Although preventative measures have been effective to some extent, risk for occupational cancer of the upper airways persists and more targeted epidemiological studies in this area are needed. A DNA transfection experiment using a chimeric JCV DNA, in which the regulatory region was derived from JCI and the other region from Mad-1, showed that the JCI regulatory region was less efficient in inducing virus production in IMR-32 cells. A dose-response graph is automatically generated by comparing the number of cells in drug-treated wells with those in control wells. The ADAM family contains disintegrin-like and metalloproteinase-like domains which potentially have cell adhesion and protease activities. The variable coupling between force and myosin light chain phosphorylation in Triton-skinned chicken gizzard fibre bundles: role of myosin light chain phosphatase.

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Low-volume discrete plasmapheresis in therapy of acute destructive lung and pleural diseases. Immunohistochemical analysis revealed the presence of interleukin-1beta in the tumor cells. These mice show phenotypes that are reminiscent of ICF patients, including hypomethylation of repetitive sequences, low body weight, distinct cranial facial anomalies and T cell death by apoptosis. Percentage of visits resulting in prescription of antibiotics, and diagnoses given. In this paper, we investigate the space complexity of the Estimation of Distribution Algorithms (EDAs), a class of sampling-based variants of the genetic algorithm. Documentation of informed consent in medical records--in hospitals and general practice. Pressure-flow characteristics were determined for four different one-way valves used for speech production in the patient who has had a tracheotomy. The results of this study also show that the anatomical arrangement of medullary cones does not permit the output from one medullary cone to enter a second medullary cone. Postischemic reperfusion causes a massive calcium overload in the myelinated spinal cord fibers.

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Two-color multiparametric method for flow cytometric DNA analysis. Biopsy specimens from seven patients were studied immunohistochemically with monoclonal antibodies. and did not appear to have resulted as a consequence of recombination with the virus genome. Neurochemical evidence that the inhibitory effect of galanin on tuberoinfundibular dopamine neurons is activity dependent. We reviewed all reports submitted to VAERS between 12/12/2002 and 3/1 2004 for post-smallpox vaccine (SPV) rashes concerning civilians and military personnel. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. In the present study, we investigated the expression and localization of these AQP10 isoforms. This is an encumbrance especially in the management of acute renal failure. Therefore, it was interesting to analyze the kinetics of micronuclei formation in lymphocytes of patients undergoing modern chemotherapy.

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Its levels decrease in sepsis and related diseases, where it has also proved to be a prognostic indicator of outcome. The selective inhibition was enhanced by sirolimus, but not cyclosporine. During the two recent decades, advocacy has been a topic of much debate in the nursing profession. Spatial tuning properties in human amblyopia cannot explain the loss of optotype acuity. AVP (0.1-100 nM) stimulated gene transcription after transient transfection of a reporter gene that was placed under the transcriptional control of a CRE. A 52-year-old man with chronic necrotizing pulmonary aspergillosis complicated by a residual tuberculous cavity was admitted to the hospital because of fever and a new infiltration shadow in the right lower lobe. Male mice of the STR/ORT strain spontaneously develop an osteoarthritis lesion in the medial tibial condyle. These findings suggest that long-term IFN-alpha therapy caused painless thyroiditis with aggravation of autoimmunity in our patient with preexisting chronic thyroiditis.

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In the event of an acute relapse the person should have direct access to the most appropriate local service. One of the monoclonals could be used to strongly and specifically stain guinea pig eosinophils in immunocytochemistry, whilst all five could be used to visualize eosinophils in suspension in BALF or peritoneal lavage fluid by flow cytometry. 30 min of ischemia plus reperfusion resulted in the release of .OH radical adducts during the period of ischemia and, especially, during the initial phases of reperfusion. The procedure provides high yields of fully active, homogeneous IFN-t and can be accomplished within 1 week. Bioarchaeological analysis of cultural transition in the southern Levant using dental nonmetric traits. Low temperature painful stimulus alters brain wave pattern of transcutaneous electrical stimulus.

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The enhancer contains a hexanucleotide direct repeat with a two bp insert which footprints with zocor crestor equivalent dose nuclear extracts from Hep3B cells and, when mutated, results in loss of hypoxic induction. Previous reports have suggested that carbohydrate structures may be conserved neutralization epitopes on retroviruses. Surviving cells were evident through 3 months postimplantation with no evidence of tumor formation. The relevance of therapeutic drug monitoring of antiretroviral agents is also discussed. Some aspects of the epidemiology of current influenza infections. Long-term follow-up of isolated pathologic, thermographic, and physiologic abnormalities preceding breast cancer. Monoclonal antibodies to immunodominant and neutralizing domains of the envelope surface protein of feline immunodeficiency virus. Anti-cytokeratin (Anti-CK) monoclonal antibodies (MAb), markers of epithelial differentiation, have been used to detect TEC subsets in rodents and humans.

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An osteoplastic flap procedure with cranialization and obliteration of the frontal sinus was performed. The transition to young adulthood: generational boundary dissolution and female identity development. The mdm-2 protein binds to both leucine-tryptophan residues at amino acids 22 and 23, from the amino terminal end of the protein, and in so doing, prevents all p53 functions. Three types of deglutition were studied: injected bolus swallows, spontaneous swallows, and visually cued swallows of boluses previously placed in the mouth. In contrast, single amino acid deletions of three N-terminal amino acids resulted in a stepwise 2700-fold reduction in affinity. We report that relative to autologous normal kidney expression of novH is elevated in Wilms tumors containing predominantly stromal elements and is inversely correlated in these tumors to the expression of WT1.

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Instead, irregular and patchy areas of necrosis are found to exist adjacent to viable tissues. Histiocytosis X (Schuller-Christian disease): a clinico-pathological survey, review of ten patients and the results of prednisone therapy. Subluxation of the peroneal tendons is also detailed with respect to diagnosis and treatment. The diffuse pattern of distribution of microvessels found in Ewing sarcoma may be responsible for the observed lack of prognostic significance of angiogenesis. A study carried out to compare the efficacy of econazole nitrate and nystatin in the treatment of vaginal candidosis showed that a three-day course of econazole nitrate pessaries was as effective as a 14-day course of nystatin pessaries and is more acceptable to patients. Antibody epitopes on the CB-11 peptide of bovine type II collagen recognized by these sera were investigated by epitope mapping. The ligand specificity and concentration dependence of receptor stabilization provide an explanation for physiological differences in the actions of T and DHT. Patterns of tumor relapse following mastectomy and adjuvant systemic therapy in patients with axillary lymph node-positive breast cancer. Expression of the C-terminal fragment of GADD34, which causes constitutive dephosphorylation of eIF2alpha, fully compensated for the stimulatory effect of alphaB-crystallin what class of antibiotic is cleocin on protein synthesis in heat-shocked cells, but only partially for that of Hsp27. The initial operations were: TOF (unicusp pulmonary valve) (re-op), two Konno procedures (one VSD and one RV patch), two arterial switch procedures for TGA (neoaortic augmentation), two Fontan (re-op) atrial augmentation patch and pulmonary arterioplasty (re-op).

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The data suggest a dual-factor hypothesis of anterior cerebral dysfunctions in alcoholism: a preexisting deficit in conceptual thinking and consequential CNS abnormality (psychomotor slowing, decreased attentiveness, and immediate memory) associated with prolonged alcohol intake, and resembling signs of premature aging. The flux and occupancy remain almost fixed within a deformation of 2.0 A but decrease sharply for a further deformation of 0.6 A. The present study aimed to examine the relationship between preferred tempi and heart rate. Treatment failure was recognized earlier in group B than in group A (4.9 vs. Content of sulfhydryl groups in the blood of pulmonary tuberculosis patients. We developed and have implemented RADCOM (RADiology COMmunicator), a computerized speech-based language translator for use during fluoroscopic examination of non-English-speaking patients. The activation energy was 14.8 kcal/mol for all four thiamines at pH 5.2 and over the temperature range of 25 to 65 degrees C. Adaptation of the aPTT as a screening test for canine hemophilia A?. fMRI (functional MRI) is a major tool to study the location of sites in the human brain. Factors influencing cardiac auscultation proficiency in physician trainees.

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Rapid genetic testing for Williams syndrome is now available using a simple cytogenetic test, fluorescence in situ hybridization, but additional work will be required for long-QT syndrome and autosomal-dominant supravalvular aortic stenosis. GLUT-1 mRNA levels were high in skeletal muscle at days 16 and 17 of fetal life and decreased markedly by days 19 and 21. A significant fraction of the genes in the Arabidopsis albendazole oral suspension ip uses tamil meaning genome is organized into chromatin domains exhibiting coregulated expression patterns in response to developmental or environmental signals. The gene expression profile of mTert-overexpressing MEFs indicates that telomerase enhances growth in these cells through the repression of growth-inhibiting genes of the transforming growth factor-beta (TGF-beta) signaling network. The HML and HMR loci are kept silent through the action of a number of proteins, one of which is the DNA-binding protein, ABF1.

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Effect of the long-term intake of Eleutherococcus on the adaptation of sailors in the tropics. Previous experiments have indicated that the central adrenergic and cholinergic systems are critically involved in this process. Application of Freundich and Langmuir isotherms were used to assess the adsorption capacity. Ultrastructural localization of nitric oxide synthase in canine small intestine and colon. Thus a liver biopsy is necessary for definitive diagnosis and treatment. These results indicate that the LP-BM5 MuLV-induced increases in brain PAF levels are the results of NMDA receptor activation and are consistent with the hypothesis that elevated CNS PAF levels contribute to the behavioral deficits observed in LP-BM5 MuLV-infected mice. Study on the life cycle of a sexually transmitted nematode parasite of a terrestrial snail. To determine if there is evidence from published reports that the use of infusion pumps or solution warmers during amnioinfusion is beneficial. The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-beta. Since there have been reports of elevated CSF concentrations of thyrotropin-releasing hormone (TRH) in depression, the authors compared the TRH levels of 17 depressed patients and 19 normal subjects.

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There was a significant deficit in total vocal responses and an increase of vocal response latency. The three groups showed no significant differences in blood pressure, plasma renin, activity and plasma aldosterone concentration. Contrast energy sensitivity takes into account the stimulus area and was therefore best for spots. The program described uses sensory integrative techniques and soft restraint to reduce face hitting in a 28 neurontin 3 mg -year-old, nonambulatory, profoundly retarded resident. Knees were implanted with Press Fit Condylar femoral, tibial, and patellar implants. In the presence of salicylate, the parent strains showed an increased level of resistance to carbapenems and quinolones and produced decreased amounts of OprD and increased amounts of OprN. Message in a ballad: the role of music preferences in interpersonal perception. To estimate the importance of defective osteoblast recruitment in the pathogenesis of this defect, we compared various histologic indices of bone formation in iliac bone biopsies in three groups of subjects--healthy premenopausal women, healthy postmenopausal women, and patients with postmenopausal osteoporosis and at least one non-traumatic vertebral compression fracture. Here, we describe a simple strategy for rapidly identifying structural domains and assessing their structures.

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Recombinant human granulocyte colony-stimulating factor (rhG-CSF) has been obtained from genetically engineered Escherichia coli as an unglycosylated protein. A method to perform a cephalic trim of the lower lateral cartilages accurately by means of the endonasal approach is discussed. In the last decade the boom in behavioural therapy studies of pain has relegated psychoanalytical publications on this topic quantitatively to the background. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Valvular surgery in the young patient with rheumatic heart disease. The association of glucose transporters (GLUT1) and brain capillaries was tested in different brain structures of rats by a direct comparison of the topologies of capillaries and GLUT1 in identical brain sections. Effects of soil surface mulching on solar greenhouse grafted and own-rooted cucumber growth and soil environment. Synthesis of platelet phospholipids, early and independent of the release reaction.

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