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Alant (Alendronate)

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Alant is FDA-approved for the treatment of postmenopausal osteoporosis, prevention of postmenopausal osteoporosis, steroid-induced osteoporosis, male osteoporosis, and Paget disease of the bone. Alant is available under the following different brand names.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

Similar Products:
Cipro, Clarinex, Tricor, Rogaine, Nuvigil, Norvasc, Omnicef, Actos, Daklinza, Hytrin

Also known as: Alendronate


Fosamax Plus D contains a combination of alendronate and cholecalciferol. Alendronate is a bisphosphonate medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

Cholecalciferol is a form of vitamin D, and is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

Fosamax Plus D is used to treat and prevent osteoporosis.


Generic Alant should be taken orally. It is recommended to take Generic Alant in liquid form once a week in the morning without food. It is recommended to take Generic Alant in tablets of 5-mg and 10-mg once a day in the morning without food. It is recommended to take Generic Alant in tablets of 30-mg and 70-mg once a week in the morning without food. It is recommended to take Generic Alant in tablets of 40-mg once a day in the morning for six months to treat Paget's disease of bone. If you want to achieve most effective results do not stop taking Generic Alant suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Drink a full glass of milk and call your local poison control center or emergency room right away. Do not make yourself vomit and do not lie down.

Overdose symptoms may include muscle cramps, numbness or tingling, tight muscles in your face, seizure (convulsions), irritability, and unusual thoughts or behavior.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alant are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Fosamax Plus D if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.

Do not take a Fosamax Plus D tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking Fosamax Plus D.

To make sure Fosamax Plus D is safe for you, tell your doctor if you have:

low blood calcium (hypocalcemia); a cancer such as sarcoidosis, leukemia, lymphoma; a vitamin D deficiency; kidney disease; or an ulcer in your stomach or esophagus.

In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Fosamax Plus D, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether Fosamax Plus D will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether alendronate and cholecalciferol passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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MR targeted imaging with biotinylated monoclonal antibody CL3 and SA-DTPA-Gd has specific enhancement effect. With respect to PB induction in female rats, the binding affinity for ethanol in the PB-treated animals is significantly larger than that observed in untreated females. Lipocortin 1 mediates an early inhibitory action of glucocorticoids on the secretion of ACTH by the rat anterior pituitary gland in vitro. Perhexiline Maleate (Px) is a potent, oxygen-sparing agent used in the management of patients with acute myocardial ischaemia that is resistant to conventional pharmacological therapy. Polysaccharide distribution in the cellular junctions of immature fibre cells of flax seedlings. Clinical observation of labor of induction with nutritional food. The vascular pedicles that can be used in women are studied from the anatomical point of view as well as the functional and technical angles in order that surgical protocols can be worked out logically for transplantation of the tubes and ovaries. In an international collaborative assay 20 laboratories compared this Standard with the Third International Standard, and the statistical analysis of the results is reported.On the basis of the results the Fourth International Standard for Insulin is established with a potency of 24.0 IU/mg. These data indicate that the peptide C9H corresponds to a region of the CD59 binding site of C9. These complex interrelationships at the glenoid humeral joint require dynamic studies to accurately evaluate normal anatomy and abnormal pathology.

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However, the evidence cannot be considered definite and the issues of possible pre-existing traits or the effects of polydrug use are not resolved. Report of Committee on Grading Lesions, Council on Arteriosclerosis, American Heart Association. Myelin basic protein mediates extracellular signals that regulate microtubule stability in oligodendrocyte membrane sheets. Cesarean section in the Northeast (Experience of the Maternidade da Encruzilhada). Impaired release of gallbladder calcitonin gene-related peptide in human gallstone disease. Currently there is no consensus on which surgical technique, timing or sequence produces optimal results. A total of 147 clients with dual disorders participated in a controlled clinical trial of three interventions--behavioral skills training, case management, and 12-step recovery--in a county mental health program. Using voxel-based morphometry (VBM), based on high-resolution magnetic resonance images, we investigated the brain structure of 28 volunteers with unilateral limb amputation and compared them to healthy controls. The TAS promises to be a useful and inexpensive tool with which to perform colonic decompression in selected patients. Microleakage was recorded as ordinal data and analyzed with nonparametric statistical tests.

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The cytochemical characteristics of the epithelium of the proximal nephron and of the endothelium of the peritubular capillaries and kidney functional status in chronic glomerulonephritis patients. The immunohistochemical staining of pp60c-src in rat testes demonstrated that pp60c-src is most abundantly expressed in the spermatids which are the spermatogenic cells in the post-meiotic phase of the spermatogenesis. Gal(alpha 1-3)Gal terminal carbohydrates are expressed by most mammals but are absent in humans, which lack a functional (alpha 1-3)galactosyltransferase gene. 252Cf plasma desorption mass spectrometry of adenomycin (C19-97 substance). Rapid determination of alpha-tocopherol in muscle and adipose tissues of pork. In this study, it was found that the carboxyl-terminal portion of the 2 subunits can be cleaved by various proteases, whereas the amino-terminal portion cannot. We have ascertained and sampled two BPES families with apparent autosomal dominant inheritance and have tested for linkage with 17 polymorphic markers on 3q.

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PMNs were studied during interaction with human umbilical vein ECs under exposure to zinc, nickel and cobalt using an in vitro model. To our knowledge, these experiments are the first to demonstrate the presence of authentic IL-2R mRNAs in a human oligodendrocyte-like cell line. The major outer membrane protein (MOMP) is the principal candidate antigen for the development of subunit vaccine against chlamydial STDs. A recent finding of reactivation of Tax-specific cytotoxic T lymphocytes (CTL) in ATL patients after hematopoietic stem cell transplantation suggests the presence of Tax expression in vivo and potential contribution of the CTL to antitumor immunity. Concerns regarding neural tube defects because of intrauterine valproate--or carbamazepine--exposure can be met by. The significance of the phenomenon of spontaneous histamine release is discussed. Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor.

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916 patients with acute myocardial infarction without history of ischaemic heart disease and 1106 controls admitted to hospital for acute conditions not related to known or suspected risk factors for ischaemic heart disease. The potential function of f5C in the tRNA(Met) anticodon is discussed with regard to codon-anticodon interactions. The Dutch data showed an earlier onset of the positivity in comparison to German. The cytomegalovirus immediate early promoter and the SV40 early promoter directed the highest amount of expression in fibroblasts while the Rous sarcoma virus LTR caused the highest amount of expression in embryos. Thus cell lineage and the manner of calcification of the transplanted tumor were similar to those of epiphyseal growth cartilage.

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Within the cochlear nucleus of the rat, as well as some nearby regions, quantitative histochemical mapping procedures were used to construct maps of the distributions of choline acetyltransferase and acetylcholinesterase activities. Serum prolactin levels were determined twice prior to surgery and at 1 and 3 weeks after surgery. General practitioners appreciated access to multiple professionals simultaneously. The production of immunoglobulins in vitro by lymphocytes from rheumatoid patients has been earlier shown to be defective. Effect of thermal and mechanical load cycling on the marginal integrity of Class II resin composite restorations. The dorsalis pedis flap was used in 3 patients, the iliofemoral (groin) flap in 4, and the latissimus dorsi myocutaneous flap in 2. Prospective calculation of doubling time, however, delays diagnosis and treatment. The thermoregulatory significance of nest building in Saccostomus campestris was investigated by examining the effect of temperature and photoperiod on the size and thermal conductance of nests built within artificial burrows by pouched mice from four localities in southern Africa that experience contrasting thermal conditions. The study included 637 patients who were undergoing transradial cardiac catheterization.

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cDNA cloning of thyroid hormone receptor beta for the Japanese flounder. Under the same experimental conditions, hepatotoxicity, as estimated by the increase of serum ornithine carbamyl transferase activity, appeared at 3 hr after 20 and 40 mg Cr/kg of Cr(VI) injection, while 10 mg Cr/kg of Cr(VI) produced no hepatotoxicity even at 12 hr. Furthermore, the AGP-like side-chains contain a style-specific epitope that is also present on AGPs from N. Molecular cloning and site-directed mutagenesis of glutathione S-transferase from Escherichia coli. Nested case-control studies were conducted within the CLUE II study, a community-based cohort, to examine the association between CRP concentrations and subsequent development of colorectal or prostate cancer. A semi-automated micro-method for the histological assessment of fat embolism. Regional coupling between chest wall and lung expansion during HFV: a positron imaging study.

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Ringed sideroblasts: a frequent observation after bone marrow transplantation. For the purpose of confirming the feasibility of proton therapy for hepatocellular carcinoma, we investigated the influence of proton therapy on liver function and also tried to evaluate the possibility of optimization using dose-volume histogram (DVH) analysis. Comment: N,N-dimethylglycine and L-carnitine as performance enhancers in athletes. Side effects were reported by three patients, which were the patients with the highest AUC. In the isolated spinal cord-cutaneous nerve preparation, the saphenous nerve-evoked slow depolarization of the L3 ventral root was augmented by the mixture of peptidase inhibitors in the presence of naloxone (0.5 microM) but not in the presence of both naloxone and a tachykinin receptor antagonist, GR71251 (5 microM). The cells are cytokeratin-negative and vimentin-positive, indicating a mesenchymal origin. They were classified into several groups according mainly to the patterns of axonal and dendritic distribution.

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Furthermore, we found increased IL-2 receptor alpha subunit mRNA expression in the peripheral blood mononuclear cells during GVHD. Deficits in spatial learning and motor coordination in ADAM11-deficient mice. The relationship between team friendships and burnout among residential counselors. The role of potential confounders of the concept of dose-response (e.g., bystander effects, genomic instability, and adaptive responses) is taking on a growing importance to the field. This has led what is the drug abilify used to treat to more logical management strategies particularly for patients with carotid artery disease.

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Observations on the utilization of a selective medium for the isolation of Erysipelothrix rhusiopathiae. Four animals served as control and were measured with both near infrared spectroscopy optodes mounted on the intact skin of the forehead, while in the remaining eight animals, one near infrared spectroscopy optode was implanted directly on the skull. Inhibition of human group II phospholipase A2 by C-reactive protein in vitro. To clarify the role of diluents in the preparation of molecularly imprinted polymers utilizing only hydrogen bonding, we investigated the effects of diluents by using different solvents. One possible approach is targeted treatment using the tyrosinase promoter for melanoma-specific expression of genes delivered by adenoviral (Ad) vectors. Peripheral blood lymphocytes (PBL) from RA patients and healthy controls were separated into a number of discrete fractions by density in discontinuous Ficoll density gradients. The aim of this study was to assess the intravenous line placement feasibility (time and success rate) in the French emergency medical system. The low-flow method uses the cardioplegia line, which goes unused during LVAD insertion. In patients with a lower acenocoumarol demand at the introduction of this therapy, a caution is required.

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Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. Like NGF, BDNF and NT-3 crosslinked to the low affinity NGF receptor (p75NGFR) on PC12 cells. The development of the nitrogen content of human organs in early fetal life. Ang-1 produced by OBs activates Tie2 on HSCs and promotes tight adhesion of HSCs to the niche, resulting in quiescence and enhanced survival of HSCs. Eye movements recorded with the magnetic-field search coil technique from six cats raised in an 8 Hz stroboscopically vasotec drug classification illuminated environment were found to be normal with the exception of fixation and optokinetic nystagmus. Translocation by T7 RNA polymerase: a sensitively poised Brownian ratchet. Visualisation of mass transport of small organic molecules and metal ions through articular cartilage by magnetic resonance imaging. Furthermore, the number of small scattered ulcers of the small intestine was significantly reduced by the high dose of FK-506 (2 mg/kg), but not by cyclosporin or prednisolone.

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After ligation of the mouse sciatic nerve we found an increase in GZ-like immunoreactivity on the proximal and distal side with time, suggesting that the alpha subunit undergoes orthograde axonal transport and also returns to the cell body by retrograde axonal transport in the sciatic nerve. Joint angle-time, angle-angle, stick and marker diagrams were used to present graphically the data following standardised procedures. In Urechis, the mRNA is particularly abundant in oocytes, but is not translated until after fertilization. Insufficient attention has been paid to the role that modern information systems does motrin help sinus infection can play in improving the delivery of and education about preventive services in family medicine training and practice sites. Phosphorus resonances consistent with phosphoarginine and ATP were observed in the in vivo 31P-nuclear magnetic resonance (NMR) spectra of infective larvae of Haemonchus contortus. Feeding and searching were significantly correlated for both direction and degree. A 63-year-old woman presented with a rapidly progressive illness resulting in coma within 24 hours from multiple myxomatous emboli. Animals were sacrificed at four circadian times (CT) relative to activity onset (CT12): CT07, 11, 14, 19 either in permanent darkness (DD) or 1 h after light stimulation. Archaic structure of the gene encoding transcription factor USF.

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Differences within and between groups revealed changes in the types and frequency of cognitive strategies. The relationship of short-circuit current (SCC, sodium transport) and potential difference (p.d.) across the toad bladder to the concentration of sodium on the mucosal side was measured. The authors have reviewed the clinical records of 110 patients with intracranial cavernous malformations diagnosed by histological examination and/or magnetic resonance imaging over a mean follow-up period of 4.71 years. PATHOPHYSIOLOGY OF HYPERTENSION: Blood pressure increases with advancing age in most developed countries. The acute administration of 15 mg metoprolol intravenously had no detectable effect on the repolarisation phase, while chronic treatment caused a significant increase of the ventricular effective refractory periods, monophasic action potential duration, and the QT interval during atrial stimulation. Our results suggest that kit ligand may be involved in the regulation of fetal macrophages, and in particular in signalling between invading extravillous trophoblast which expresses kit ligand, and maternal leukocytes bearing the c-kit receptor. No negative effects were found on the neuropsychological development in this cohort of children, even if they had been exposed to maternal anti-Ro/SSA antibodies and to very high dosages of DEX (much higher than those used to improve fetal lung maturity). Dermal infiltrate abounds with eosinophils, basophils, neutrophils propranolol inderal la 80 mg 24 hr capsule , and mononuclear cells several hours after challenge. In this study, we investigated the role of gp42, a glycoprotein component of the extracellular enveloped form of vaccinia virus (EEV) encoded by the B5R gene.

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Linear Programming is used to calculate average path lengths among proteins and the network diameter as measures of functionality. All patients were reviewed one month later by endoscopy and/or X Ray. On the basis of simple statistical mechanical models, the prevailing view of the rings of Saturn is that they are unstable and must therefore have been formed rather recently. Proliferating tubular epithelial cells were also clearly identified. It should be used as a basis for care and provide the fundamentals to successfully treat patients in a trauma setting. However, a low grade malignant lymphoma should also be included in the differential diagnosis. Prolactin and gonadal hormones: a key relationship that may have clinical, monitoring and therapeutic implications in systemic lupus erythematosus. Surgery of lung metastasis--indications, results and prognostic factors as an interdisciplinary concept. The cost-benefit ratio of this expensive drug must be considered, however. Our recent observations have indicated that a p60 TNF receptor-associated kinase (p60-TRAK) from U-937 cells physically interacts with and causes the phosphorylation of the cytoplasmic domain of the TNF receptor.

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200 precancerous patients were treated by the drug Hua-sheng-ping, the process was monitored by endoscopic histo-pathologic examination, and biochemical criteria. Peritoneal fluid eosinophil counts were noted to be elevated soon after catheter insertion and initiation of peritoneal dialysis. Chlamydia trachomatis was found to be the aetiological agent of endometritis in three women with concomitant signs of salpingitis. Immunoblots showed that IGFBP-4 resolved into at least three spots of approximately 29K, with pI values of about 6.3-6.7 and an approximately 24K nonglycosylated form that usually appeared as a single spot with a pI of about 7, but occasionally it resolved into a doublet. Pure congenital mitral insufficiency (apropos of 3 personal anatomoclinical cases).

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Retrospective analysis of postoperative chemotherapy with UFT against pancreatic cancer. Spinal administration of N-methyl-D-aspartate (NMDA, 0.5 nmol), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA, 0.1 nmol) or substance P (SP, 0.5 nmol) to the rat provoked a specific behaviour characterized by biting, scratching and licking (BSL). The stimuli were then removed and one of the nonsense syllable names was given by the experimenter. On the problem of the possibility of utilization of dodecylgallate as an antioxidant of dietary fats. Oxygen deprivation induces the production of a low, but detectable amount of MDA in both heart and brain, whereas reperfusion causes a marked increase of MDA in both tissues. Pheochromocytoma is a rare disease that may occur during pregnancy. Inflammatory stimuli and provision of nutrients are important factors regulating both total liver protein synthesis and albumin synthesis. The resulting growth of polydihexylfluorene brushes from the patterned surface was monitored by contact angle, optical spectrometry, surface profilometry and AFM.

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In this independent group design, EOD data and blood were collected from subjects over 15 days. The effect of wrist size on the orthodromic median sensory nerve action potential. Therefore, we examined the mechanism of the proliferation by analyzing Fgf10(-/-) mouse embryonic WAT, in which adipogenesis and proliferation were severely impaired. The effect of trauma and confinement on functional health and mental health status of Cambodians living in Thailand-Cambodia border camps. The different lymphocytic reaction seems to be the consequence of different immune responses of the lymphatic system. Activities of 6 lysosomal enzymes in leukocytes and 3 enzymes in blood serum were studied in pregnant women. Persons treated for a sexually transmitted disease have been shown to be at increased risk for human immunodeficiency virus infection. Clearance studies on the effect of vasoactive substances on the blood supply and glomerular filtration of the kidneys.

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This publication updates the reference plasma and red blood cell protein maps obtained with immobilized pH gradients. Two models were built in order to appraise the modelling capability when different drawing programs are used to create the set of molecules. The effects of UVC on human skin is rarely studied, but we know that UVB can be harmful. To identify receptors potentially mediating this effect, we tested for RNA transcripts of the three known alpha subunits of strychnine binding site, using the reverse transcription-polymerase chain reaction. Proceedings of the IVth International Symposium on Schistosomiasis and the IV National Meeting on Schistosomiasis. Consistent with the activity of endogenous PAL transcripts, wounding of rice and tobacco leaf tissues induced GUS activity from low basal levels. In both types of capillaries there was a basement membrane and an extracellular space containing collagen.

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