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Adefin (Nifedipine)

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Adefin is used to treat hypertension (high blood pressure) and angina (chest pain). Adefin is in a class of drugs called calcium channel blockers. Adefin relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Other names for this medication:
Adalate, Adefin, Adipine, Amarkor, Anpect, Atenerate, Calcianta, Calcibloc, Chronadalate, Cisday, Conducil, Coral, Cordilat, Cordipin, Corotrend, Depine, Ficard, Ficor, Jutadilat, Lemar, Menoprizin, Myogard, Nedipin, Nidicard, Nidilat, Nifatenol, Nifebene, Nifecor, Nifedalat, Nifedical, Nifedipress, Niften, Nipin, Nirena, Sepamit, Vasdalat, Viscard

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Also known as: Nifedipine


Adefin is a perfect remedy in struggle against hypertension or high blood pressure, angina or chest pain. Adefin acts by relaxing blood vessels (such as veins and arteries), which makes it easier for the heart to pump and reduces its workload. Adefin is also known as Nifedipine, Nicardia, Nifedical, Procardia. Generic name of Adefin is Nifedipine. Brand names of Adefin are Adefin CC, Procardia, Procardia XL.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalat PA 20. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Adalat dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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The failure to obtain representative biopsies for histology could be explained by the deep situation of tumors below the surface epithelium. After culture in vitro, these cells shown increase susceptibility to undergoing spontaneous apoptosis, that is enhanced by IL-4 and prevented by IL-1beta or LPS. Mass screening of prostate cancer in a Chinese population: the relationship between pathological features of prostate cancer and serum prostate specific antigen. Genetic and physiological studies have indicated that sigma interacts with promoter DNA sequences but biochemical analysis did not demonstrate DNA binding by the sigma subunit itself. Low blood urea nitrogen (BUN) and serum cholesterol values in wild lemurs (compared to those of North American captive zoo ruffed lemurs) may suggest differences between diets in the wild and captivity. (3) A high index of suspicion is necessary to detect spinal and extraspinal infections. The specific lack of expression of DQ Ags correlated with undetectability of newly synthesized DQ alpha beta heterodimers, as assessed by biosynthetic labeling and immunoprecipitation with a variety of DQ-specific mAbs. We propose adaptive management strategies that we believe will enable the bottomland hardwoods to regenerate and support their associated biota and that are reasonable, flexible, and economically sustainable.

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A consistency of the T cell repertoire over the course of MS and ON should facilitate the development of specific immunotherapies. Toxic effects induced in rabbits by extracellular products and sonicates of group A streptococci. Pasteurella haemolytica leukotoxin induces histamine release from bovine pulmonary mast cells. The use of hydroxyapatite with ultrahigh dispersity in the combined treatment of patients with mandibular fractures. Several studies have suggested that nausea and vomiting in early pregnancy are related to the levels of thyroid hormones and human chorionic gonadotropin (hCG).

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Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells. Antibiotics, lactulose, and dietary manipulation should be initiated as soon as hepatic encephalopathy is suspected. Percutaneous transluminal angioplasty using a Stealth catheter, 3.0-mm diameter and 10-mm long, successfully dilated the stenosis. The results for clozapine were contrasted with previous reports indicating that haloperidol has little effect on lick rhythm. For this process, we determined the crystal structure of wild-type mouse apoE, which, like apoE4, forms a four-helix bundle, and identified two structural differences in the turn between helices 2 and 3 and in the middle of helix 3 as potentially destabilizing sites.

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Brain infections in human immunodeficiency virus positive patients. This increased sensitivity seems to affect an induction of a sub-G1 population as assessed from flow cytometry analysis. Manual performance as a function of rate of change in hand skin temperature. So far the rational approach to antifungal discovery, in which compounds are optimized against an individual target then progressed to efficacy against intact fungi and ultimately to infected humans has delivered no new agents. A beta1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction. With an average follow-up of 4.6 years, 39 per cent of the patients were cured, 27 per cent improved, 31 per cent unchanged and none worsened. In our case the patient initially developed coliform peritonitis followed by peritoneal and systemic candidiasis. This study was designed to identify secular trends in age at menarche, at first cigarette, and at first use of oral contraceptives among a large population-based sample of young Israeli women and to assess whether these trends are associated with sociodemographic factors. Following co-introduction of the phiC31 integrase expression plasmid and the plasmid carrying attB, the efficiency of integration into the unmodified human genome was assessed.

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Spying the neutralizing epitopes on E2 N-terminal by candidate epitope-vaccines against classical swine fever virus. Risk and adaptive behaviors are markers of sexual intentions among black preadolescents. Increasing cell density down-regulates the expression of acidic FGF by human RPE cells in vitro. Understanding how a single genome can produce a variety of different phenotypes is of fundamental importance in evolutionary and developmental biology. To evaluate the effects of supraceliac and infrarenal aortic cross-clamping on the expression of neutrophil integrin in CD11b (a marker of systemic cytokine release). Treatment of murine thymocytes or spleen cells with thiol-reactive HgCl2, a known inducer of autoimmune proliferative lymphocyte disorders in rodents, was found to induce tyrosine phosphorylation of several cellular proteins, which was up to 100 times as extensive as that triggered by stimulation with antireceptor antibody or mitogen.

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On the other hand, following 1 min of ischemia which failed to induce tolerance, no increase in the bcl-2 oncoprotein was observed. The relationship between ethanol intake and DSM-III-R alcohol dependence: results of a national survey. Play behaviours and play object preferences of young children with autistic disorder in a clinical play environment. No retinal or corneal complications secondary to IOL removal and re-implantation through levaquin sulfa drug a limbal approach could be detected over an average follow-up period of 22.3 months (range, 17-27 months). This may relate to the status of target tissue GH receptors that appear subject to down regulation in the adult chicken. A planning study to analyze the impact of different leaf widths on the achievable dose distributions with intensity modulated radiation therapy (IMRT). Hence, MMP-activated doxorubicin prodrugs have a much higher therapeutic index than doxorubicin using HT1080 xenografts as a preclinical model. Magnet recognition for nursing excellence--is your organization there yet?. The cerebellar cortex is also the site where error signals from other parts of the central nervous system are incorporated. A case of septic cavernous sinus thrombosis in 41 year old men is described.

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The excretion of pethidine and its metabolite norpethidine is increased in acid urine and decreased in alkaline urine. Variability in automatic activation as an unobtrusive measure of racial attitudes: a bona fide pipeline?. By contrast, the histone H1 kinase activity of p34cdc2 estimated in microtubular oocyte pellets was much higher in metaphase than in prophase oocytes. QT dispersion in 12 lead ECG reflects the heterogeneity of ventricular repolarisation. With each scientific advancement or new technology there will continue to be the need for efficient organizations to provide acute care to the patients who will benefit most. These is pepcid 20 mg prescription measurements were not significantly affected by photobleaching or depth profile at acquisition. Cell biology in orthodontic tooth movement: the known and the unknown. Repeated tianeptine treatment prevented the CMS-induced increase in CRF mRNA levels in the dBNST, and reduced CRF mRNA levels in dBNST in non-stressed controls. Perioperative data were abstracted from the acute pain management service clinical database and linked to follow-up data captured four weeks postoperatively.

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These results present evidence for the involvement of the GABA-benzodiazepine receptor complex in the pathogenesis of ethanol-induced gastric damage. Immunocytochemistry has an important role in establishing the diagnosis. Intrapreoptic application of beta-END caused a rapid decline of LH release in ovx rats which was completely cozaar blood pressure medicine reversible after termination of beta-END perfusion. Several organs, including lung, liver, and kidney, contained positive-staining cells for WSP, confirming that the canine host does come into contact with Wolbachia-derived molecules. An injectable silicone lens was implanted in one eye of six rhesus monkeys who were older than 17 years. A recombinant polypeptide composed of the alpha-helical neck region and carbohydrate recognition domain (CRD) of bovine conglutinin was expressed in Escherichia coli. Iron status and growth of rats fed different dietary iron sources. To address this challenge, we have developed a Microrarray PowerAtlas. Extinction of Vibrio cholerae in acidic substrata: contaminated cabbage and lettuce treated with lime juice. This study assessed the influence of background genome on expression of genes linked to DNA fingerprint (DFP) bands in chickens.

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Multiple Drug Resistance (MDR) gene related glycoproteins are believed to act as the drug efflux pump. The wild type gene and all mutant genes were overexpressed and the gene products purified to homogeneity. To resolve this problem, understanding of the normal development of the peripheral nervous system is needed. The evidence for all these potential chemopreventive agents is critically reviewed. Both ears of 30 healthy adults were tested at 5 different galvanic stimulation rates (1, 3, 5, 7 and 9 Hz) in a random order. These findings support the use of ER-targeting PROTACS as probes of angiogenesis. Interrelationships in the urinary excretion of creatine, creatinine, free alpha amino acid nitrogen, and total nitrogen in premature infants. Spectrum of looping disturbances in stage 34 chicken hearts after retinoic acid treatment. The effect of HDAC1 on cell cycle exit is cell-autonomous, and loss of HDAC1 in the retina leads to up-regulation of cyclin D and E transcripts.

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Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain. An intranuclear isotope labelling technique in which the fate of cells what drugs interact with robaxin labelled with I125-iododeoxyuridine (I125UdR) is monitored, has been adapted for use with dogs. Lymphocyte migration from the blood to sites of tissue injury is mediated, in part, through the interaction of these cells with endothelial cells lining the vessel walls. Acidic fibroblast growth factor facilitates generation of long-term potentiation in rat hippocampal slices. Using quail/chick grafts, we show that this embryonic appendage autonomously produces endothelial cells and hematopoietic cells, these latter being endowed with the attributes of the definitive hematopoietic lineage. Pickwickian syndrome and indications for surgically induced weight loss. The magnification afforded by the positive add increases spatial grain and thereby enhances visibility of detail in an ageing visual system free of any gross senile pathology. By comparing photoelectron images of uncoated and metal-coated MCF-7 human breast carcinoma cells, it is shown that the problem is specimen charging rather than a fundamental limitation of the electron imaging process.

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Fixation of distal radius fractures using a fragment-specific system. Among the 16 women who reported pain, this occurred above all when the tubes were grasped (10 cases). The dosimetry data indicate that adequate doses can be administered for clinical imaging without exposing the patient to excessive radiation. End diastolic pressure in the evaluation of left-ventricular myocardial insufficiency in ischemic heart disease. Rectal mucosal IL-8 measurement might be an additional objective diagnostic tool that can predict relapse in patients with quiescent UC. Ulcerative colitis is associated with many ocular complications. A hydrea max dose prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients--an interim analysis.

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Possibilities and limitations of various methods of radiological study of the breast, with special reference to pneumostratigraphy. The use of trypsin and chymotrypsin by parenteral administration in the treatment of some bronchopneumopathies. A comparison of dental caries experience in Native American and Caucasian children in Oklahoma. In the univariant regression analysis the correlation coefficients among serum PSA and transition zone, peripheral zone and central zone volumes were 0.934, 0.546 and 0.368, respectively, strongly suggesting that most PSA leakage from the prostate into the serum comes from the transition zone. Novel pathophysiological concepts of inflammatory bowel disease. Thus, both a 130-kDa glycoprotein and certain gangliosides are implicated in the attachment of the actinomyces to PMNs. Inhibition of guinea pig complement by maleopimaric acid and other derivatives of levopimaric acid. Generally, a favourable response to local treatment may be anticipated only if the distal two-thirds of the nail is affected. Our analysis of the RT heterodimerization enhancing non-nucleoside RT inhibitor (NNRTI), efavirenz, indicates that the effects of drugs on RT dimer stability can be examined in human cells. The intestinal juices free the ovum from its cuticle and, having entered a capillary, it is carried by the blood stream to the liver or lung, where it develops into a hydatid cyst.

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