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Adaret (Adapalene)

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Adaret works well for treating mild-to-moderate acne, but it can cause burning and itching right after using it. The medication has many different formulations, but only the lower strength gel is available over-the-counter.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Trileptal, Mobic, Colospa, Micardis, Differin, Lodine, Lozol, Imodium, Singulair

Also known as: Adapalene


Differin (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Differin is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Follow the directions for using this medicine provided by your doctor. Use Adaret exactly as directed. Adaret is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Adaret. Adaret should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Adaret. Continue using Adaret until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Adaret promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Differin dosage information

Side effects

The most common side effects associated with Adaret are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Differin if you are allergic to adapalene.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions.

It is not known whether adapalene passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

It is not known whether Differin will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

Differin is not approved for use by anyone younger than 12 years old.

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Factors affecting the stability of the renal sodium/phosphate symporter during its solubilization and reconstitution. As a prerequisite for blocking specific gene expression in the brain, the pharmacokinetics of two radiolabelled analogs of antisense oligodeoxyribonucleotides (unmodified O-ODN and nuclease resistant phosphorothioate S-ODN) were examined by infusion into the baso-lateral nucleus of amygdala. After slaughter (7th post-operative day) was evaluated the peritoneal adhesions at posterior wall. In addition, an over-all reduction in procedure time has been achieved by this method. A total of 204 medial and lateral treatment fields were evaluated in 102 breast cancer patients treated with conservative surgery and radiation therapy. New possibilities for immunisation against travellers diarrhoea are appraised. This study provides one of the longest follow-up periods of breast cancer survivors to date among studies that focus on QOL and is unique in its focus on women diagnosed at a young age.

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Effects of ursodeoxycholic acid on hemodynamic and renal function abnormalities induced by obstructive jaundice in rats. The enzyme operates predominantly by a transglycosylic mechanism, i.e., by random splitting the beta-(1,4)-linked polyglucose backbone of xyloglucan molecules and rejoining the newly created reducing ends by beta-(1,4) glycosidic bonds to nonreducing ends of other xyloglucan molecules or xyloglucan subunit oligosaccharides. Higher susceptibility to thiol compounds of a protease in healing sites of Arthus-type inflammation and its biological significance. The most potent of these is C108g, directed against a type-specific epitope in HXB2 and BaL gp120s, which is glycan dependent and, in contrast to previous reports, dependent on intact disulfide bonds. Role of nitric oxide in resistance and histopathology during experimental infection with Trypanosoma cruzi. Correct preoperative diagnosis of CF demands high index of suspicion and determines the success of laparoscopic management for the subset of patients. Both female and male salivary gland lysates exhibited phosphatase enzymatic activity but the specific activities were lower than those seen for the esterase enzymatic activity. This paper is a review of their chemical structures, nomenclature and biological actions.

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Species-specific detection of venom antigens from snakes of the Bothrops and Lachesis genera. Conflicting results in the literature concerning the influence of overlearning on subsequent feeling of knowing (FOK) judgments for unrecallable items were resolved in an experiment that contrasted within-subject and between-subject designs. Metallic stents in malignant biliary obstruction: results of a multicenter European study of 240 patients. To study human TOR in vitro, we have produced in large scale both the full-length TOR (289 kDa) and a truncated TOR (132 kDa) from HEK293 cells. After 6 hours in collagen gel, considerable membrane remodeling had occurred as determined by a reduction in outer membrane microvilli. Here we report that rat treatment with DAS and PIC significantly decreased the trapping of hydroxyethyl free radicals in liver microsomes incubated in vitro with ethanol. Prognostic value of intra-left ventricular electromechanical asynchrony in patients with mild hypertrophic cardiomyopathy compared with power athletes. This paper deals with kinetics of quality changes during food frying.

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