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Acyclovir

Aciclovir (ACV) is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein-Barr virus infection.

Other names for this medication:
Aciherpin, Acirax, Acivir, Acloriv, Acvirall, Acvirax, Acycloguanosine, Acyclor, Acyclovir, Acylab, Alovir, Axovir, Cevirin, Civir, Clovir, Cutivir, Cycloex, Cyclopiz, Docvir, Herperax, Herpex, Herporax, Kayvir, Lyrovir, Ocurax, Ocuvir, Okavir, Optiviral, Oveer, Rivol, Rovir, Rowapil, Trikase, Virclo, Viroderm, Viroxit, Virucid, Vivorax, Zovir

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Description

Zovirax (acyclovir) is an antiviral drug. Acyclovir slows the growth and spread of the herpes virus in the body.

Zovirax is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chickenpox.

Zovirax will not cure herpes, but it can lessen the symptoms of the infection.

Dosage

Patient information about the treatment of herpes, chickenpox, or shingles is available with this medicine. Read it carefully before using this medicine.

Acyclovir is best used as soon as possible after the symptoms of herpes infection or shingles (for example, pain, burning, blisters) begin to appear.

If you are taking acyclovir for the treatment of chickenpox, it is best to start taking acyclovir as soon as possible after the first sign of the chickenpox rash, usually within one day.

Acyclovir capsules, tablets, and oral suspension may be taken with meals or on an empty stomach.

Acyclovir is best taken with a full glass (8 ounces) of water.

If you are using acyclovir oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your herpes infection, chickenpox, or shingles, keep taking acyclovir for the full time of treatment, even if your symptoms begin to clear up after a few days. Do not miss any doses. However, do not use this medicine more often or for a longer time than your doctor ordered.

If you are taking acyclovir capsules, tablets, or oral suspension, you should drink plenty of water to avoid becoming dehydrated.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, oral suspension, or tablets): For treatment of genital herpes: Adults and children 12 years of age and older—200 milligrams (mg) five times a day for ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For prevention of recurrent outbreaks of genital herpes infections: Adults and children 12 years of age and older—200 to 400 mg two to five times a day for five days or up to twelve months, depending on how often your outbreaks of infection occur. Children up to 12 years of age—Use and dose must be determined by the doctor. For treatment of chickenpox: Adults and children who weigh over 88 pounds (40 kilograms)—800 mg four times a day for five days. Children 2 years of age and older and weighing 88 pounds (40 kilograms) or less—Dose is based on body weight and must be determined by the doctor. The usual dose is 20 mg per kilogram (kg) of body weight, up to 800 mg, four times a day for five days. Children up to 2 years of age—Use and dose must be determined by the doctor. For treatment of shingles: Adults and children 12 years of age and older—800 mg five times a day for seven to ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For injection dosage form: For treatment of herpes of the brain, genitals, or mucous membranes, or for the treatment of shingles: Adults and children 12 years of age and older—Dose is based on body weight and must be determined by the doctor. The usual dose is 5 to 10 mg of acyclovir per kg (2.3 to 4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period, and repeated every eight hours for five to ten days. Children up to 12 years of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg to 20 mg of acyclovir per kg (4.5 mg to 9.1 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for seven to ten days. For treatment of widespread herpes virus infection in newborns: Infants from birth to 3 months of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg of acyclovir per kg (4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for ten days.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acyclovir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Zovirax Topical if you are allergic to acyclovir or valacyclovir (Valtrex).

Zovirax Topical is not approved for use by anyone younger than 12 years old.

Tell your doctor if you have ever had a weak immune system (caused by disease or by using certain medicine).

It is not known whether this medicine will harm an unborn baby. However, herpes virus can be passed from an infected mother to her baby during childbirth. If you have genital herpes, it is very important to prevent herpes lesions during your pregnancy, so that you do not have a genital lesion when your baby is born.

You should not breastfeed if you have a herpes lesion on or near your breast.

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This implies two distinct modes of repression and raises the question: how does the transition from early transient repression to stable Pc-G-mediated repression occur?. These results suggest the involvement of catalytically-active Cu(II) and glucose dysregulation in oxidative stress reactions leading to tissue damage in both diseases. Upon starvation, the ULK1 complex forms puncta associated with the ER and sporadically with mitochondria. Anti-Streptococcus mutans property of a chitosan: Containing resin sealant. In conclusion, the present meta-analysis results markedly indicate that MMP-9 expression is associated with clinicopathological features of bladder cancer, suggesting that MMP-9 may be a useful biomarker in the diagnosis and clinical management of bladder cancer, and may be a valuable therapeutic target. Surface hydrophobicity of the gastric mucosa was reduced by stress, but was maintained at prestress levels by treatment with milk, cream, or their lipid extracts, although this effect was not sufficient for protection in stressed rats. A follow-up evaluation of 133 psychiatric patients from units other than the Third Infantry Division.

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Deliveries following a successful ECV are associated with an increased CS rate compared with deliveries of fetuses with spontaneous cephalic presentations. The fluorescent amino acids were located at position 122 of the tropomyosin primary sequence, corresponding to a solvent-exposed position c of the coiled-coil heptapeptide repeat. Increases in the secretion of endogenous GLP-1 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes. Commentary: Supplier-dependent differences in intermittent voluntary alcohol intake and response to naltrexone in Wistar rats. Bronchoscopic and bronchobioptic diagnosis of pulmonary forms of sarcoidosis of Besnier-Boeck-Schaumann. Elevated expression of tumor miR-222 in pancreatic cancer is associated with Ki67 and poor prognosis. The study sought to identify factors associated with outcomes of metastatic ESCC in patients who were treated with three-drug combinations. We have undertaken studies designed to identify differences in how the TFIIIA gene is transcribed in oocytes and somatic cells. A greater understanding of the theoretical underpinnings of resilience in nursing and midwifery students is essential for the development of educational resources. The TT cDNA was obtained by screening a commercial (Clonetech) pig liver cDNA library in lambda gt11, using polyclonal antibodies raised in rabbits against pig liver TT.

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