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Aciclovir (ACV) is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein-Barr virus infection.

Other names for this medication:
Aciherpin, Acirax, Acivir, Acloriv, Acvirall, Acvirax, Acycloguanosine, Acyclor, Acyclovir, Acylab, Alovir, Axovir, Cevirin, Civir, Clovir, Cutivir, Cycloex, Cyclopiz, Docvir, Herperax, Herpex, Herporax, Kayvir, Lyrovir, Ocurax, Ocuvir, Okavir, Optiviral, Oveer, Rivol, Rovir, Rowapil, Trikase, Virclo, Viroderm, Viroxit, Virucid, Vivorax, Zovir

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Zovirax (acyclovir) is an antiviral drug. Acyclovir slows the growth and spread of the herpes virus in the body.

Zovirax is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chickenpox.

Zovirax will not cure herpes, but it can lessen the symptoms of the infection.


Patient information about the treatment of herpes, chickenpox, or shingles is available with this medicine. Read it carefully before using this medicine.

Acyclovir is best used as soon as possible after the symptoms of herpes infection or shingles (for example, pain, burning, blisters) begin to appear.

If you are taking acyclovir for the treatment of chickenpox, it is best to start taking acyclovir as soon as possible after the first sign of the chickenpox rash, usually within one day.

Acyclovir capsules, tablets, and oral suspension may be taken with meals or on an empty stomach.

Acyclovir is best taken with a full glass (8 ounces) of water.

If you are using acyclovir oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your herpes infection, chickenpox, or shingles, keep taking acyclovir for the full time of treatment, even if your symptoms begin to clear up after a few days. Do not miss any doses. However, do not use this medicine more often or for a longer time than your doctor ordered.

If you are taking acyclovir capsules, tablets, or oral suspension, you should drink plenty of water to avoid becoming dehydrated.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, oral suspension, or tablets): For treatment of genital herpes: Adults and children 12 years of age and older—200 milligrams (mg) five times a day for ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For prevention of recurrent outbreaks of genital herpes infections: Adults and children 12 years of age and older—200 to 400 mg two to five times a day for five days or up to twelve months, depending on how often your outbreaks of infection occur. Children up to 12 years of age—Use and dose must be determined by the doctor. For treatment of chickenpox: Adults and children who weigh over 88 pounds (40 kilograms)—800 mg four times a day for five days. Children 2 years of age and older and weighing 88 pounds (40 kilograms) or less—Dose is based on body weight and must be determined by the doctor. The usual dose is 20 mg per kilogram (kg) of body weight, up to 800 mg, four times a day for five days. Children up to 2 years of age—Use and dose must be determined by the doctor. For treatment of shingles: Adults and children 12 years of age and older—800 mg five times a day for seven to ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For injection dosage form: For treatment of herpes of the brain, genitals, or mucous membranes, or for the treatment of shingles: Adults and children 12 years of age and older—Dose is based on body weight and must be determined by the doctor. The usual dose is 5 to 10 mg of acyclovir per kg (2.3 to 4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period, and repeated every eight hours for five to ten days. Children up to 12 years of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg to 20 mg of acyclovir per kg (4.5 mg to 9.1 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for seven to ten days. For treatment of widespread herpes virus infection in newborns: Infants from birth to 3 months of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg of acyclovir per kg (4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for ten days.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Acyclovir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Zovirax Topical if you are allergic to acyclovir or valacyclovir (Valtrex).

Zovirax Topical is not approved for use by anyone younger than 12 years old.

Tell your doctor if you have ever had a weak immune system (caused by disease or by using certain medicine).

It is not known whether this medicine will harm an unborn baby. However, herpes virus can be passed from an infected mother to her baby during childbirth. If you have genital herpes, it is very important to prevent herpes lesions during your pregnancy, so that you do not have a genital lesion when your baby is born.

You should not breastfeed if you have a herpes lesion on or near your breast.

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Evidence for specific complex formation between alpha-melanocyte stimulating hormone and 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infrared Fourier transform Raman spectroscopy. Similarly, in nocturnal rodents, bright light can either facilitate or disrupt performance depending on the type of task employed. However, contrast enhancement cannot be used to reliably distinguish infectious from noninfectious inflammatory conditions. The pathogenesis and diagnosis of canine hip dysplasia: a review. In order to understand this platelet anomaly, we discuss the data available in the literature. Early excision avoids the development of a permanent neurologic deficit.

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A main cause of hepatitis A and B infections in European countries is travel to endemic countries. Large prospective studies are needed to evaluate the surgical trauma and optimal number of perioperative complications. Promising targets are galectins (Gal), due to their strong expression in and on PDAC-cells and occurrence at early stages in cancer precursor lesions, but not in adjacent normal tissues. In nature, plants have to cope with a wide range of stress conditions that often occur simultaneously or in sequence. The automatic, frequent, and noninvasive measurements obtained with the biographer provides more information about glucose levels than the current standard of care. The increased expression of cyclin B-Cdk1 and decreased activity of the Cdk1 inhibitor and cell cycle checkpoint proteins (mei-41 and grp) in Ago-1 mutant embryos allow the nuclei to enter into mitosis prematurely, even before completion of DNA replication. The study concludes that the AIDS severity classification facilitates interhospital comparisons of illness levels and variations in resource use. The Na,K-ATPase alpha 2 subunit gene displays restriction fragment length polymorphisms between the genomes of normotensive and hypertensive rats. Biophysical testing proved that G-quadruplex conformations were efficiently stabilized or induced by G-quadruplex ligands in all three sequences. Evolution of viral quasispecies in interferon-treated patients with chronic hepatitis C virus infection.

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Pathogenesis of demyelinating encephalomyelitis (including acute multiple sclerosis) and polyneuritis. Apoptosis in transmyocardial and percutaneous myocardial revascularization. Endovascular treatment of the infrapopliteal arteries in hemodialysis patients with critical limb ischemia: is it justified?. Pediatric caregiver attitudes toward email communication: survey in an urban primary care setting. The diagnosis was made on culture of the pus from the abscess and upon biopsy and histological examination of the skin lesion from the toe. The authors conclude that pH-metry by slight application of the pH electrode to the gastric wall raises the validity of the values recorded and reduces the frequency of incomplete vagotomy in patients operated on in the clinic by 4.7 times. Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action. These associations raise the question of causality: is alcohol somehow neurotoxic, or can we identify specific psychological and cognitive variables that serve as risk factors for the escalation of heavy drinking?. We manipulated nitrogen (control or 4 g/m(2)), phosphorus (control or 0.5 g/m(2)), soil biota (untreated or sterilized field soil), and plant origin (4 populations from the invasive range, 4 populations from the native range) in a full factorial experiment. In this review, we discuss the common methods used for inducing each of the pain phenotypes related to clinical pain syndromes as well as the main behavioral tests for assessing pain in each model.

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Today religion faces the difficult task to integrate scientific knowledge into its teaching. Here, we report that the expression of a 250-kDa mosaic LDLR family member, which we called LR11 for the presence of 11 ligand-binding repeats, is markedly induced during the process of atherogenesis in 2 animal models. The latter was found to be exerted by two independent genes with the dominant alleles determining good responses to IL-2. The results are good for 16 patients, nul for 2 patients and we observed 2 complications. Possible explanations for this finding are discussed, including low exposure, exposure, and outcome misclassification, together with inappropriateness, nonvalidity, and relative insensitivity of neuropsychological tests. We report a rare case of antenatally detected unilateral pelvi-ureteric junction obstruction leading to congenital giant hydronephrosis presenting as upper abdominal mass at birth. The presence of morphologically abnormal eosinophils in the bone marrow and/or peripheral blood has been rarely reported as a prominent feature in myelodysplastic syndromes (MDS). The authors describe the implementation and evaluation of a 1-year psychopharmacology course using residents-as-teachers and active-learning exercises intended to improve understanding of current psychopharmacology and its evidence base, and skills for life-long learning. Rapid access to N-(indol-2-yl)amides and N-(indol-3-yl)amides as unexplored pharmacophores.

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Negative and positive elements in the promoter region of the human apoferritin L gene. There is a lack of studies comparing the utility of C-reactive protein (CRP) with Procalcitonin (PCT) for the management of patients with acute respiratory tract infections (ARI) in primary care. Immune Responses Induced by Recombinant Bacillus Subtilis Expressing the Hemagglutinin Protein of H5N1 in chickens. Several factors including cytokines, leptin, and mechanical forces are pathogenic factors of knee OA. Analysis of dynamic nuclear cardiac images by covariance function. The FJS and OKS questionnaire results of the two groups were then compared. Patients were followed for a mean period of 54 months (range, 12-72 mo). Primary brain damage that occurs at the time of injury can be exacerbated and prolonged for months or even years by chronic inflammatory processes, which can ultimately lead to secondary cell death, neurodegeneration, and long-lasting neurological impairment.

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Use of total simultaneous cerebral angiography by intravenous approach in children. Synergistic action of protein kinase C theta and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis imovane reviews pathway in Jurkat T cells. Because the explored variables can change over time they call for a longitudinal research approach. Thiocyanate-free ruthenium(II) sensitizer with a pyrid-2-yltetrazolate ligand for dye-sensitized solar cells. In addition, activation of the heat-shock response and a loss of nucleoid-occluded ribosomes are observed. DRG-based per diem payment system matches costs more accurately. muciniphila, but not with Escherichia coli, prior exposure to DSS also resulted in a reduction of colitis severity, highlighting that the anti-inflammatory effect of the gut microbiota of C-IBS patients is mediated, in part, by A.

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Highly Stereo- and Regioselective Hydrocarboxylation of Diynes with Carbon Dioxide. Direct radiolabeling methods currently rely on the addition of exogenous chemical reagents to create the necessary binding sites for 99mTc binding to monoclonal antibodies (MAbs). A case of acute eosinophilic pneumonia: bronchoalveolar lavage findings before and after steroid treatment. In this study, we have identified a critical role for the interaction between apoptosis-linked gene 2 (ALG-2) and heme-binding protein 2 (HEBP2) in the above processes. The characteristics of the participation of the neostriatal cholinergic system in regulating different forms of defensive behavior. Likewise, knockdown of Rab8a or Rab11a in primary SCs also suppressed axonal outgrowth from co-cultured dorsal root ganglion (DRG) neurons.

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Retrospective analysis with standardized questionnaire including 33 consecutive patients treated with redo-urethroplasty for bulbar or penile strictures. Among them, compound 24S showed stereospecific and excellent TRPV1 antagonism of capsaicin-induced activation. However, the starting point of recurrences differed in each group. It was found that in vascular pathology of the visual nerve due to atherosclerosis, both in the involved and clinically healthy eye different degrees of visual nerve atrophy develop due to sclerotic changes in the blood vessels. Effects of ultraviolet light on some of the electrical characteristics of action potentials of single unmyelinated nerve fibers of the crab Carcinus. The expression and localization of specific TGF-beta receptors in the lung, however, have not yet been investigated. These observations suggest that different parts of the PDL of the rat lower incisor may have different functional significances such as force generation of tooth eruption and mechanical resistance to occlusal pressure and continuous growth. In cases where the thymoma has infiltrated the surrounding organs, the extent of the infiltration should be used to determine whether to select TRT, or median sternotomy.

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Aromatic and antiaromatic ring currents in a molecular nanoring. Statistical analyses indicated that low miR-218 expression was closely associated with poor tumor differentiation, advanced tumor stage, higher incidence of lymph node metastasis, and tumor recurrence. Here we designed two silk-R5 fusion proteins that differed in the location of the R5 peptide, C- vs. The recombinant protein self-assembly into virus like particles and possess antigenicity as reference IBDV. In the process, it also secretes 1,25(OH)2D3, which exerts a suppressive action to dampen this response. Incubation with n-LDL or ox-LDL did not affect either the contractile detrol davis drug guide pdf or the relaxant response of rings. A link to a web-based survey of surfactant administration methods was emailed to the directors of all neonatal units in the Nordic Region, apart from Finland, where only the five university-based departments were invited. Stimulation of rat peritoneal mast cells enhances uptake of low density lipoproteins by rat peritoneal macrophages in vivo.

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This implies two distinct modes of repression and raises the question: how does the transition from early transient repression to stable Pc-G-mediated repression occur?. These results suggest the involvement of catalytically-active Cu(II) and glucose dysregulation in oxidative stress reactions leading to tissue damage in both diseases. Upon starvation, the ULK1 complex forms puncta associated with the ER and sporadically with mitochondria. Anti-Streptococcus mutans property of a chitosan: Containing resin sealant. In conclusion, the present meta-analysis results markedly indicate that MMP-9 expression is associated with clinicopathological features of bladder cancer, suggesting that MMP-9 may be a useful biomarker in the diagnosis and clinical management of bladder cancer, and may be a valuable therapeutic target. Surface hydrophobicity of the gastric mucosa was reduced by stress, but was maintained at prestress levels by treatment with milk, cream, or their lipid extracts, although this effect was not sufficient for protection in stressed rats. A follow-up evaluation of 133 psychiatric patients from units other than the Third Infantry Division.

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Deliveries following a successful ECV are associated with an increased CS rate compared with deliveries of fetuses with spontaneous cephalic presentations. The fluorescent amino acids were located at position 122 of the tropomyosin primary sequence, corresponding to a solvent-exposed position c of the coiled-coil heptapeptide repeat. Increases in the secretion of endogenous GLP-1 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes. Commentary: Supplier-dependent differences in intermittent voluntary alcohol intake and response to naltrexone in Wistar rats. Bronchoscopic and bronchobioptic diagnosis of pulmonary forms of sarcoidosis of Besnier-Boeck-Schaumann. Elevated expression of tumor miR-222 in pancreatic cancer is associated with Ki67 and poor prognosis. The study sought to identify factors associated with outcomes of metastatic ESCC in patients who were treated with three-drug combinations. We have undertaken studies designed to identify differences in how the TFIIIA gene is transcribed in oocytes and somatic cells. A greater understanding of the theoretical underpinnings of resilience in nursing and midwifery students is essential for the development of educational resources. The TT cDNA was obtained by screening a commercial (Clonetech) pig liver cDNA library in lambda gt11, using polyclonal antibodies raised in rabbits against pig liver TT.

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