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Acroli (Tacrolimus)

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Acroli is used to stop your body from attacking or rejecting your transplanted organ. The typical starting dose will be based on your weight, the type of transplant you received, and the other immunosuppressants you're taking. After a few days, your dose will be adjusted based on your blood tests.

Other names for this medication:
Acroli, Crolim, Cromus, Mustopic, Olmis, Pangraf, Protopic, Seegraf, Tacloran, Tacrel, Tacrim, Tacroderm, Tacrograf, Tacrokid, Tacrolimus, Tacromus, Tacrotor, Tacrovate, Tacroz, Tacstead, Talimus, Tarcel, Techlomus, Topgraf, Triplibact, Vingraf

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Also known as: Tacrolimus


Tacrolimus injection is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the direct supervision of a doctor.


Take Prograf exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may receive an injection of Prograf shortly after your transplant. The injection is given until you are ready to take the pill form of tacrolimus.

Take Prograf at the same time each day, with a full glass of water.

Swallow the capsule whole and do not crush, chew, break, or open it.

Mix Prograf oral granules with water right before you take them. Do not save this mixture for later use. Do not get the powder or mixture on your skin or in your eyes. If this happens, wash your skin with soap and water or rinse your eyes with water.

You may take Prograf with or without food, but take it the same way each time.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. All forms of tacrolimus are not equivalent and may not have the same dose or schedule. Avoid medication errors by using only the form and strength your doctor prescribes.

You will need frequent medical tests, and your blood pressure will need to be checked often.

Store at room temperature away from moisture and heat.

Detailed Prograf dosage information


If you overdose Generic Acroli and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acroli are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Prograf if you are allergic to tacrolimus or hydrogenated castor oil, or if you have used cyclosporine (Neoral, Sandimmune, Gengraf) within the past 24 hours.

Using Prograf may increase your risk of developing serious infections or certain types of cancer, such as lymphoma or skin cancer. Your risk may be higher if you are treated over long periods of time with drugs that weaken the immune system. Ask your doctor about this risk and about symptoms to watch for.

Some people taking Prograf after a kidney transplant have developed diabetes. This effect has been seen most commonly in people who are Hispanic or African-American.

To make sure Prograf is safe for you, tell your doctor if you have::

problems with your liver, kidney, or heart that are not related to your transplant; long QT syndrome (in you or a family member); or if you are scheduled to receive a vaccine;

Tell your doctor if you plan to get pregnant. Tacrolimus may harm an unborn baby, and can worsen conditions such as diabetes or high blood pressure in the mother. Use effective birth control before and during treatment with Prograf.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of tacrolimus on the baby.

If you are a man, use birth control before and during treatment with Prograf if your sex partner is able to get pregnant.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

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Immunosuppressive activity induced by nitric oxide in culture supernatant of activated rat alveolar macrophages. Di-O-sulfates of six phytoestrogenic isoflavonoids, daidzein (1), genistein (2), glycitein (3), and the reduced metabolites dihydrodaidzein (4), dihydrogenistein (5) and equol (6) were synthesized. The roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro. Correlation between tumour antigens and malignancy in BKV-transformed hamster cells. Septin: a factor in plasma that opsonizes lipopolysaccharide-bearing particles for recognition by CD14 on phagocytes. Takayasu arteritis and giant cell arteritis are included in large-vessel vasculitis.

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Automation bias (AB) happens when users become overreliant on decision support, which reduces vigilance in information seeking and processing. Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway disease: metabolic changes that unravel novel drug targets. Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. Significant decrease of protein level in non-pregnant rats treated with high DFU dose, and occasionally observed gastrointestinal changes were the only changes noted in groups exposed to the selective COX-2 inhibitor. Structural analysis and fatty acid-binding properties of two Croatian variants of human serum albumin. The optimal goal of radiography is to provide high-quality diagnostic images with the least patient radiation dose. The role of group I and group II metabotropic glutamate receptors in modulation of striatal NMDA and quinolinic acid toxicity. brasiliensis is cultured under conditions which did not support sporulation. Regulation of immune activity by mild (fever-range) whole body hyperthermia: effects on epidermal Langerhans cells. In the present immunocyto-chemical study, we determined the detailed cellular and subcellular localization of SSeCKS in mouse tissues after LPS administration, and examined the involvement of SSeCKS in the uptake of exogenous particles.

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Univentricular atrioventricular connection with subaortic stenosis: a staged surgical approach. Epitopes contained in the laminin A chain are absent from the molecule, and a 190-kD chain substitutes for the A chain. Preoperative serum samples and tumor specimens were prospectively collected in 100 patients undergoing resection of HCC. Moreover, with increasing QDs size, a pronounced MPT is observed. Equine Rhinitis A Virus Mutants with Altered Acid Resistance Unveil a Key Role of VP3 and Intrasubunit Interactions in the Control of the pH Stability of the Aphthovirus Capsid. Failure of thalidomide to influence homograft immunity in chickens. Abnormal CSF immunoglobulin components detected by isoelectric focusing. Although it is uncertain how health care will evolve in the future, we at Kaiser Permanente are committed to maintaining and expanding our involvement in the education of the next generation of surgeons. A DNA sequence flanking the autonomous Spm insertion was verified to be o2-specific and provided a probe to clone a wild-type allele. Glia were identified using anti-glial fibrillary acid protein (GFAP), antivimentin, and cleocin gel size anti-cellular retinaldehyde binding protein antibodies.

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