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Aclene (Adapalene)

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Aclene is used to treat acne. Aclene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin. Aclene has the unique ability to inhibit keratinocyte differentiation and decrease keratin deposition.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Adaferin, Adapalene, Adapen, Adaple, Adgraze, Adiff, Adina, Aditop, Alangel, Apalene, Apgel, Clinred, Daple, Difra, Edplin, Faceclin, Labopene, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Hytrin, Hydrea, Prilosec, Imodium, Kemadrin, Valtrex

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Usual Adult Dose for Acne:

Differin 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Differin 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Differin dosage information


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Differin dosage information

Side effects

The most common side effects associated with Aclene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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Plasmids 180 and 170 kb in size, present in the relapsing fever agents B. Using the acute ischemic model of rats and patch-clamp techniques, the effects of the M3 receptor on the occurrence of arrhythmias and its possible mechanisms were studied. The same effects were obtained using platelets from atopic donors directly stimulated with anti-IgE. Trimethoprim/sulfamethoxazole is commonly used to treat melioidosis. Colorimetric estimation of phospholipids in aqueous dispersions: addendum. Peripheral blood stem cells were harvested by leukapheresis after first and second consolidation therapies. Sequence based approaches for finding homology have broad use for annotation of both structure and function. The visualization of localized or diffuse echogenicity was chosen as the characteristic ultrasonographic finding of cystic teratoma. Diversity and redundancy in bacterial chromosome segregation mechanisms. Alfuzosin in the treatment of benign prostatic hyperplasia: effects on symptom scores, urinary flow rates and residual volume.

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Study on changes in circulatory renin-angiotensin system in rats with endotoxemia. Long-term effects of LDL apheresis in patients with severe hypercholesterolemia. Review of police, medical examiner, and crime laboratory records for all firearm homicides and review of medical examiner records for all suicides and unintentional and undetermined firearm fatalities. The diagnosis and treatment of incipient and early idiopathic scoliosis. Hepatitis B virus: biology, natural history, and diagnosis of the infection. Lack of excision of introns from primary transcripts of certain chicken vitellogenin II minigenes. On CD4 positive lymphocytes, the majority of the described effects on the integrin and adhesion receptors was seen on cells bearing the CD45R0 maturational epitope. Physiologic reactions during 5 weeks of continuous residence i an artificial humid and hot climate. Intracerebral hemorrhage after therapeutic upper-GI endoscopy: report of a case. Involvement of protein kinase A in ethanol-induced locomotor activity and sensitization.

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Induction of nitric oxide synthase in rat immune complex glomerulonephritis. The in vitro evaluation of antimicrobial properties revealed the strong activity of Sn(C6H5)2(Hdpa)Cl2 and Sn(C6H5)3Cl(OH2).Hdpa complexes. Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver. Time-dependent changes in Bolton-Hunter-labeled 125I-substance P binding in rat spinal cord following unilateral adjuvant-induced peripheral inflammation. The effects of low-pass filtering on the primary cortical auditory potential of the rat. Changes in the hydroxyproline and hexosamine content of grafts after transplantation. Early central nervous system response to HIV infection: sleep distortion and cognitive-motor decrements. IL-10 also reduced B7 up-regulation on IFN-gamma-stimulated monocytes.

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Analysis of the cytokine response of the cells persistently infected with C. Splenic vein thrombosis is reported here as an unusual consequence of nephrotic syndrome in the dog. A colorimetric procedure for the determination of triose phosphate and fructose-1,6-diphosphate in presence of other sugars. Classical conditioning of the rabbit eyeblink response was used to study the effects of cerebellar lesions on performance in animals trained with low-intensity unconditioned stimuli (US). Changes in the fine structure of erythrocytes during haemolysis by vitamin A. Comparison of somatosensory evoked fields to airpuff and electric stimuli. The system shows a series of concentration and velocity patterns, or phases, with varying rotation rate and solvent viscosity. Simple method for the analysis of tenoxicam in human plasma using high-performance liquid chromatography. These findings establish the first known function for Dlg1 in virus-mediated cellular transformation and also surprisingly expose a previously unrecognized oncogenic activity encoded by this suspected cellular tumor suppressor gene. coli under oxygen deprived conditions and extracted physiologically relevant patterns that represent an adaptation of the cells to changing environmental conditions.

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